Abstract:　Removal　of　low　content　of　Cr(VI)　from　water　is　a　critical　challenge　for　water　environment　protection.　Herein,　an　acrylamide-thiosemicarbazide　cellulose　aerogels　(ATC)　was　designed　by　dissolving,　grafting　and　freeze-drying　to　introduce　thiosemicarbazide　onto　acrylamide-cellulose　aerogels　(AMC)　via　Schiff　based　reaction.　The　resultant　ATC　was　further　employed　as　an　efficient　adsorbent　to　remove　low　content　of　Cr(VI)　from　wastewater　by　adsorption　and　reduction.　The　SEM,　FT-IR,　and　BET　results　showed　that　the　ATC　was　composed　of　well-developed　pore　structure　and　owned　functional　groups　such　as　–NH2,　C–S　and　C=S　groups.　Experimental　results　indicated　that　ATC　exhibited　excellent　removal　efficiency　for　99%　under　low　initial　concentration　(0.1–10 mg/L).　The　adsorption　isotherms　demonstrated　ATC　adsorbent　according　to　a　monolayer　adsorption　behavior　following　the　Langmuir　model　with　a　calculated　maximum　adsorption　capacity　of　83.40 mg/g　at　pH　3,　and　the　adsorption　kinetics　well　obeyed　the　pseudo-first-order　kinetic　model.　Importantly,　the　maximum　effluent　concentration　of　Cr(VI)　was　lower　than　0.045 mg/L,　meeting　the　standard　of　WHO　(50 μg/L).　Furthermore,　the　main　removal　mechanisms　involved　the　synergistic　effect　of　electrostatic　interactions,　reduction　and　chelation　between　the　positively　charged　functional　groups　of　adsorbent　and　the　anionic　Cr(VI)　ions.　Graphic　Abstract:　[Figure　not　available:　see　fulltext.]　©　2020,　Springer　Science+Business　Media,　LLC,　part　of　Springer　Nature.