Charge　carriers　separation　and　surface　catalytic　reactions　are　two　crucial　steps　in　photocatalytic　processes;　the　rational　design　of　photocatalysts　by　taking　these　two　factors　into　consideration　is　thus　of　great　importance　to　advance　the　associated　performance.　Herein,　a　self-sacrificial　strategy　is　developed　to　fabricate　a　ternary　nanostructure　photocatalyst,　forming　a　hierarchical　architecture　of　In(OH)3　nanocube　decorated　NiS-ZnIn2S4　(ZIS)　hybrid　nanosheets　(ZIS/In(OH)3-NiS).　Such　a　unique　structure　provides　the　hybrid　photocatalyst　with　a　facilitated　path　for　efficiently　separating　the　charge　carrier　and　abundant　sites　for　catalytic　reactions.　Systematic　characterizations　that　reveal　the　strong　electronic　interactions　in　the　ternary　ZIS/In(OH)3-NiS　leads　to　fast　electron　transfer　from　excited　ZnIn2S4　to　NiS　nanosheets,　which　provide　catalytic　sites　for　hydrogen　evolution　reaction.　The　comprehensive　photocatalysis　studies　demonstrate　that　ZnIn2S4/In(OH)3-NiS　exhibits　ultrahigh　photocatalytic　activity　toward　hydrogen　generation　with　a　high　rate　of　7010　μmol　g−1h−1,　which　ranks　as　one　of　the　highest　among　ZnIn2S4-based　photocatalysts　reported　so　far.　This　work　provides　an　attractive　and　effective　way　to　develop　high-activity　photocatalysts　without　using　precious　metal　cocatalysts.　The　investigation　brings　us　one　step　closer　to　understanding　the　structure-determining　properties　of　nanohybrid　architecture,　and　provides　a　valuable　reference　to　develop　cost-effective　and　practical　photocatalysts　for　a　variety　of　applications.　©　2020　WILEY-VCH　Verlag　GmbH　&　Co.　KGaA,　Weinheim