Alginate-zinc (II) phthalocyanine conjugates: Synthesis, characterization and tumor-associated macrophages-targeted photodynamic therapy - Details

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Abstract：

Tumor-associated　macrophages　(TAMs)-targeted　photodynamic　therapy　(PDT)　has　dual-selectivity　and　hence　is　promising　in　cancer　treatment.　Since　the　scavenger　receptor-A　(SR-A)　on　TAMs　can　recognize　polyanions,　two　molecular-weight　sodium　alginates　(SA1,　41.2　kDa;　SA2,　1231.5　kDa)　were　herein　respectively　conjugated　with　1-[4-(2-aminoethyl)　phenoxy]　zinc　(II)　phthalocyanine　(1)　and　two　novel　conjugates　were　obtained,　characterized　and　evaluated　for　their　TAMs-targeted　PDT　efficacy.　The　SA　introduction　makes　1　water-soluble,　less　aggregated　and　capable　of　emitting　considerable　fluorescence　in　water.　Compared　with　1,　both　conjugates,　especially　1-SA1,　can　give　higher　selectivity　and　photocytotoxicity　to　SR-A-positive　macrophages　J774A.1　than　SR-A-negative　HepG2　cells.　The　in　vivo　biodistribution　evaluation　shows　both　conjugates　can　selectively　accumulate　at　the　tumor　site　and　1-SA1　owns　higher　tumor　accumulation.　1-SA1　can　achieve　an　87　%　tumor　inhibition　rate　without　observable　systemic　toxicity.　These　results　reveal　the　great　potential　of　SA　as　a　carrier　for　conjugating　anti-tumor　drugs　and　1-SA1　for　TAMs-targeted　PDT.　©　2020　Elsevier　Ltd

Keyword：

Alginate; Conjugate; Photodynamic therapy; Phthalocyanine; Tumor-associated macrophage; Tumor-targeting therapy

Community：

[ 1 ] [Tang, F.]College of Chemistry, State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou, 350108, China
[ 2 ] [Xie, W.]College of Chemistry, State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou, 350108, China
[ 3 ] [Li, S.]College of Chemistry, State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou, 350108, China
[ 4 ] [Hu, Q.]College of Chemistry, State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou, 350108, China
[ 5 ] [Zheng, B.]College of Chemistry, State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou, 350108, China
[ 6 ] [Ke, M.]College of Chemistry, State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou, 350108, China
[ 7 ] [Huang, J.]College of Chemistry, State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou, 350108, China

Reprint 's Address：

[Tang, F.]College of Chemistry, State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou UniversityChina

Email：

hellotfx@fzu.edu.cn

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Source ：

Carbohydrate Polymers

ISSN： 0144-8617

Year： 2020

Volume： 240

9 . 3 8 1

JCR@2020

1 0 . 7 0 0

JCR@2023

ESI HC Threshold：160

JCR Journal Grade：1

CAS Journal Grade：1

Cited Count：

WoS CC Cited Count： 0

SCOPUS Cited Count： 16

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 3

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