Lithium　is　deemed　as　the　anticipated　anode　for　the　next-generation　energy　storage　system.　Nevertheless,　its　commercial　application　is　greatly　hindered　by　the　uneven　deposition　and　volume　expansion　in　the　process　of　lithium　plating　and　stripping.　Here,　a　three-dimensional　lithiophilic　current　collector　with　in　situ　grown　CuO　nanowire　arrays　on　Cu　foam　has　been　demonstrated　to　effectively　ameliorate　the　above　problems.　Beneficial　from　the　large　specific　surface　area　and　lithiophilicity　properties,　CuO　nanowire　arrays　prominently　diminish　the　local　current　density　and　nucleation　overpotential,　resulting　in　uniform　lithium　deposition.　Moreover,　the　optimized　anode　exhibits　a　prolonged　lifespan　for　more　than　280　cycles　at　0.5　mA　cm-2　and　a　high　coulombic　efficiency　of　95.5%　for　over　150　cycles　at　3　mA　cm-2　in　an　assembled　half　cell,　which　is　maintained　steadily　for　540　h　in　a　symmetric　cell　with　good　capacity　retention　capabilities　in　a　full　cell.　This　facile　approach　provides　a　feasible　strategy　to　realize　stable　lithium　deposition　and　a　high-performance　lithium　metal　anode.　Copyright　©　2020　American　Chemical　Society.