Protective Mechanism of Common Buckwheat (Fagopyrum esculentum Moench.) against Nonalcoholic Fatty Liver Disease Associated with Dyslipidemia in Mice Fed a High-Fat and High-Cholesterol Diet - Details

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Abstract：

This　study　aimed　to　investigate　the　protective　mechanism　of　common　buckwheat　(Fagopyrum　esculentum　Moench.)　against　nonalcoholic　fatty　liver　disease　(NAFLD)　associated　with　dyslipidemia　in　mice　that　were　fed　a　high-fat　and　high-cholesterol　diet　(HFD).　Results　showed　that　oral　supplementation　of　common　buckwheat　significantly　improved　physiological　indexes　and　biochemical　parameters　related　to　dyslipidemia　and　NAFLD　in　mice　fed　with　HFD.　Furthermore,　the　HFD-induced　reductions　in　fecal　short-chain　fatty　acids　were　reversed　by　common　buckwheat　intervention,　which　also　increased　the　fecal　bile　acid　(BA)　abundance　compared　with　HFD-induced　hyperlipidemic　mice.　Liver　metabolomics　based　on　ultraperformance　liquid　chromatography-quadrupole　time-of-flight　mass　spectrometry　demonstrated　that　common　buckwheat　supplementation　made　significant　regulatory　effects　on　the　pentose　phosphate　pathway,　starch　and　sucrose　metabolism,　primary　BA　biosynthesis,　and　so　forth.　The　results　of　high-throughput　sequencing　revealed　that　common　buckwheat　supplementation　significantly　altered　the　structure　of　the　intestinal　microbiota　in　mice　fed　with　HFD.　The　correlations　between　lipid　metabolic　parameters　and　intestinal　microbial　phylotypes　were　also　revealed　by　the　heatmap　and　network.　Additionally,　common　buckwheat　intervention　regulated　the　mRNA　expressions　of　genes　responsible　for　liver　lipid　metabolism　and　BA　homeostasis,　thus　promoting　BA　synthesis　and　excretion.　These　findings　confirmed　that　common　buckwheat　has　the　outstanding　ability　of　improving　lipid　metabolism　and　could　be　used　as　a　potential　functional　food　for　the　prevention　of　NAFLD　and　hyperlipidemia.　©　2020　American　Chemical　Society.

Keyword：

common buckwheat; dyslipidemia; intestinal microbiota; liver metabolomics; non-alcoholic fatty liver disease

Community：

[ 1 ] [Huang, Z.-R.]College of Food Science, Fujian Agriculture and Forestry University, Fuzhou Fujian, 350002, China
[ 2 ] [Huang, Z.-R.]National Engineering Research Center of JUNCAO Technology, Fujian Agriculture and Forestry University, Fuzhou Fujian, 350002, China
[ 3 ] [Deng, J.-C.]School of Ocean Science and Biochemistry Engineering, Fuqing Branch, Fujian Normal University, Fuqing Fujian, 350300, China
[ 4 ] [Li, Q.-Y.]Institute of Food Science and Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou Fujian, 350108, China
[ 5 ] [Li, Q.-Y.]College of Science and Engineering, Fuzhou University of International Studies and Trade, Fuzhou Fujian, 350202, China
[ 6 ] [Cao, Y.-J.]Institute of Food Science and Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou Fujian, 350108, China
[ 7 ] [Cao, Y.-J.]College of Food Science, Fujian Agriculture and Forestry University, Fuzhou Fujian, 350002, China
[ 8 ] [Cao, Y.-J.]National Engineering Research Center of JUNCAO Technology, Fujian Agriculture and Forestry University, Fuzhou Fujian, 350002, China
[ 9 ] [Lin, Y.-C.]Institute of Food Science and Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou Fujian, 350108, China
[ 10 ] [Lin, Y.-C.]College of Food Science, Fujian Agriculture and Forestry University, Fuzhou Fujian, 350002, China
[ 11 ] [Lin, Y.-C.]National Engineering Research Center of JUNCAO Technology, Fujian Agriculture and Forestry University, Fuzhou Fujian, 350002, China
[ 12 ] [Bai, W.-D.]College of Light Industry and Food Science, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, China
[ 13 ] [Liu, B.]College of Food Science, Fujian Agriculture and Forestry University, Fuzhou Fujian, 350002, China
[ 14 ] [Liu, B.]National Engineering Research Center of JUNCAO Technology, Fujian Agriculture and Forestry University, Fuzhou Fujian, 350002, China
[ 15 ] [Rao, P.-F.]Institute of Food Science and Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou Fujian, 350108, China
[ 16 ] [Ni, L.]Institute of Food Science and Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou Fujian, 350108, China
[ 17 ] [Lv, X.-C.]Institute of Food Science and Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou Fujian, 350108, China
[ 18 ] [Lv, X.-C.]College of Food Science, Fujian Agriculture and Forestry University, Fuzhou Fujian, 350002, China
[ 19 ] [Lv, X.-C.]National Engineering Research Center of JUNCAO Technology, Fujian Agriculture and Forestry University, Fuzhou Fujian, 350002, China

Reprint 's Address：

[Lv, X.-C.]Institute of Food Science and Technology, College of Biological Science and Technology, Fuzhou UniversityChina

Email：

xucong1154@163.com

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Source ：

Journal of Agricultural and Food Chemistry

ISSN： 0021-8561

Year： 2020

Issue： 24

Volume： 68

Page： 6530-6543

5 . 2 7 9

JCR@2020

5 . 7 0 0

JCR@2023

ESI HC Threshold：116

JCR Journal Grade：1

CAS Journal Grade：1

Cited Count：

WoS CC Cited Count： 0

SCOPUS Cited Count： 26

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 5

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