A non-aggregated silicon(IV) phthalocyanine-lactose conjugate for photodynamic therapy - Details

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Abstract：

To　develop　a　highly　efficient　photosensitizer　for　photodynamic　therapy　(PDT),　we　have　designed　and　synthesized　a　phthalocyanine-lactose　conjugate　(Pc-Lac)　through　axial　modification　of　silicon(IV)　phthalocyanine　with　lactose　moieties.　With　the　lactose　substituents,　Pc-Lac　is　highly　hydrophilic　and　non-aggregated　with　efficient　reactive　oxygen　species　(ROS)　generation　in　aqueous　media.　With　these　desirable　properties,　Pc-Lac　shows　high　photocytotoxicity　and　cellular　uptake　toward　HepG2　cells.　In　addition,　in　vivo　fluorescence　imaging　shows　that　Pc-Lac　could　selectively　remain　at　tumor　site,　leading　to　its　enhanced　photodynamic　efficacy　against　H22　tumor-bearing　mice.　Therefore,　Pc-Lac　shows　a　great　potential　as　a　highly　efficient　molecular　photosensitizer　for　PDT.　©　2020　Elsevier　Ltd

Keyword：

Hydrophilicity; Lactose; Non-aggregated; Photodynamic therapy; Phthalocyanine

Community：

[ 1 ] [Li, D.]State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 2 ] [Hu, Q.-Y.]State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 3 ] [Wang, X.-Z.]State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 4 ] [Li, X.]State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 5 ] [Hu, J.-Q.]State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 6 ] [Zheng, B.-Y.]State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 7 ] [Ke, M.-R.]State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 8 ] [Huang, J.-D.]State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou, 350108, China

Reprint 's Address：

[Ke, M.-R.]State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou UniversityChina

Email：

kemeirong@fzu.edu.cn

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Source ：

Bioorganic and Medicinal Chemistry Letters

ISSN： 0960-894X

Year： 2020

Issue： 12

Volume： 30

2 . 8 2 3

JCR@2020

2 . 5 0 0

JCR@2023

ESI HC Threshold：160

JCR Journal Grade：2

CAS Journal Grade：3

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count： 25

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 0

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