The　enzymatic　reaction-distillation　coupling　process　is　a　promising　technology　to　realize　the　chiral　resolution　of　(R/S)-1-phenylethanol　with　ethyl　butyrate　and　ethanol　as　acyl　donor　and　byproduct,　respectively.　In　order　to　design　such　a　coupling　process,　the　vapor-liquid　equilibrium　(VLE)　data　are　necessary.　However,　these　data　were　incomplete　in　literatures.　In　this　work,　the　isobaric　VLE　experiments　were　conducted　at　101.3　kPa　for　the　binary　systems　of　1-phenylethanol　+　ethyl　butyrate,　1-phenylethanol　+　ethanol,　1-phenylethyl　butyrate　+　ethyl　butyrate,　1-phenylethyl　butyrate　+　ethanol,　and　1-phenylethyl　butyrate　+1-pheny　ethanol.　Additionally,　the　saturated　vapor　pressure　of　1-phenylethyl　butyrate　was　measured　in　the　temperature　range　420-500　K　and　correlated　with　the　Antoine　equation.　Both　the　Non-Random　Two　Liquid　(NRTL)　and　Wilson　models　were　used　for　the　correlation　of　experimental　VLE　data.　Both　models　showed　satisfactory　accuracy,　although　the　Wilson　model　performed　slightly　better　than　the　NRTL　model.　This　work　would　provide　important　thermodynamic　information　for　the　design　of　enzymatic　reaction-distillation　coupling　process　to　realize　the　chiral　resolution　of　(R/S)-1-phenylethanol.　©　2020　American　Chemical　Society.