An Ultrasound Activated Vesicle of Janus Au-MnO Nanoparticles for Promoted Tumor Penetration and Sono-Chemodynamic Therapy of Orthotopic Liver Cancer - Details

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Abstract：

Sonodynamic　therapy　(SDT)　has　the　advantages　of　high　penetration,　non-invasiveness,　and　controllability,　and　it　is　suitable　for　deep-seated　tumors.　However,　there　is　still　a　lack　of　effective　sonosensitizers　with　high　sensitivity,　safety,　and　penetration.　Now,　ultrasound　(US)　and　glutathione　(GSH)　dual　responsive　vesicles　of　Janus　Au-MnO　nanoparticles　(JNPs)　were　coated　with　PEG　and　a　ROS-sensitive　polymer.　Upon　US　irradiation,　the　vesicles　were　disassembled　into　small　Janus　Au-MnO　nanoparticles　(NPs)　with　promoted　penetration　ability.　Subsequently,　GSH-triggered　MnO　degradation　simultaneously　released　smaller　Au　NPs　as　numerous　cavitation　nucleation　sites　and　Mn2+　for　chemodynamic　therapy　(CDT),　resulting　in　enhanced　reactive　oxygen　species　(ROS)　generation.　This　also　allowed　dual-modality　photoacoustic　imaging　in　the　second　near-infrared　(NIR)　window　and　T1-MR　imaging　due　to　the　released　Mn2+,　and　inhibited　orthotopic　liver　tumor　growth　via　synergistic　SDT/CDT.　©　2020　Wiley-VCH　Verlag　GmbH　&　Co.　KGaA,　Weinheim

Keyword：

chemodynamic therapy; Janus nanoparticles; self-assembly; sonodynamic therapy; ultrasound

Community：

[ 1 ] [Lin, X.]MOE key laboratory for analytical science of food safety and biology Institution, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 2 ] [Liu, S.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350108, China
[ 3 ] [Zhang, X.]MOE key laboratory for analytical science of food safety and biology Institution, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 4 ] [Zhu, R.]MOE key laboratory for analytical science of food safety and biology Institution, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 5 ] [Chen, S.]MOE key laboratory for analytical science of food safety and biology Institution, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 6 ] [Chen, X.]Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, United States
[ 7 ] [Song, J.]MOE key laboratory for analytical science of food safety and biology Institution, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 8 ] [Yang, H.]MOE key laboratory for analytical science of food safety and biology Institution, College of Chemistry, Fuzhou University, Fuzhou, 350108, China

Reprint 's Address：

[Song, J.]MOE key laboratory for analytical science of food safety and biology Institution, College of Chemistry, Fuzhou UniversityChina

Email：

jibinsong@fzu.edu.cn

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Source ：

Angewandte Chemie - International Edition

ISSN： 1433-7851

Year： 2020

Issue： 4

Volume： 59

Page： 1682-1688

1 5 . 3 3 6

JCR@2020

1 6 . 1 0 0

JCR@2023

ESI HC Threshold：160

JCR Journal Grade：1

CAS Journal Grade：2

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count： 277

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 1

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