Login | Cas Login
English| 简体中文| 繁体中文

  • Complex
  • Title
  • Keyword
  • Abstract
  • Scholars
  • Journal
  • ISSN
  • Conference
成果搜索

Advanced Search

author：

Chen, S. (Chen, S..) [1] | Wu, J. (Wu, J..) [2] | Tang, Q. (Tang, Q..) [3] | Xu, C. (Xu, C..) [4] | Huang, Y. (Huang, Y..) [5] | Huang, D. (Huang, D..) [6] | Luo, F. (Luo, F..) [7] | Wu, Y. (Wu, Y..) [8] | Yan, F. (Yan, F..) [9] | Weng, Z. (Weng, Z..) [10] | Wang, S. (Wang, S..) [11]

Indexed by：

Scopus

Abstract：

In　this　study,　amphiphilic　conjugates　were　synthesized　by　conjugating　curcumin　(CUR)　to　a　food-derived　hydrophilic　hydroxyethyl　starch　(HES)　via　an　acid-labile　ester　linker.　The　self-assembly　of　the　conjugates　formed　uniform　micellar　nanoparticles　(HES-CUR　NPs)　with　a　desirable　drug　loading　efficiency,　excellent　colloidal　and　storage　stability,　as　well　as　acid-responsive　release　manner.　Besides,　the　formation　of　the　nanoparticles　increased　the　solubility　of　CUR　to　thousands　times　higher　than　free　CUR,　and　effectively　protected　the　loaded　CUR　from　degradation　upon　exposure　to　UV　light　and　high　temperature.　In　vitro　cytotoxicity　assay　and　radical　scavenging　experiments　demonstrated　that　the　HES-CUR　NPs　significantly　improved　the　cytocompatibility,　anticancer　and　antioxidant　activity　of　CUR　due　to　the　enhanced　solubility,　stability,　and　bioavailability.　The　HES-CUR　NPs　reported　herein　have　a　great　potential　in　developing　functional　food　or　pharmaceutical　formulations　for　preventing　or　treating　various　diseases　such　as　inflammatory　diseases　and　cancer.　©　2019　Elsevier　Ltd

Keyword：

Anticancer; Antioxidant; Curcumin; Hydroxyethyl starch; Micellar nanoparticle; Stability

Community：

  • [ 1 ] [Chen, S.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, Fujian 350116, China
  • [ 2 ] [Wu, J.]Department of Vascular Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, China
  • [ 3 ] [Tang, Q.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, Fujian 350116, China
  • [ 4 ] [Xu, C.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, Fujian 350116, China
  • [ 5 ] [Huang, Y.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, Fujian 350116, China
  • [ 6 ] [Huang, D.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, Fujian 350116, China
  • [ 7 ] [Luo, F.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, Fujian 350116, China
  • [ 8 ] [Wu, Y.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, Fujian 350116, China
  • [ 9 ] [Yan, F.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, Fujian 350116, China
  • [ 10 ] [Weng, Z.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, Fujian 350116, China
  • [ 11 ] [Wang, S.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, Fujian 350116, China

Reprint 's Address：

  • [Huang, D.]College of Biological Science and Engineering, Fuzhou UniversityChina

Email：


huangda@fzu.edu.cn
Show more details

Related Keywords：

Related Article：

Source ：

Carbohydrate Polymers

ISSN： 0144-8617

Year： 2020

Volume： 228

9 . 3 8 1

JCR@2020

1 0 . 7 0 0

JCR@2023

ESI HC Threshold：160

JCR Journal Grade：1

CAS Journal Grade：1

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count： 98

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 3

Affiliated Colleges：

Get Fulltext

DOI Library Discovery Baidu Scholar Search SCOPUS
Online/Total：369/10034080
Address：FZU Library(No.2 Xuyuan Road, Fuzhou, Fujian, PRC Post Code：350116) Contact Us：0591-22865326
Copyright：FZU Library Technical Support：Beijing Aegean Software Co., Ltd. 闽ICP备05005463号-1