Salt　(sodium　chloride)　is　an　essential　dietary　requirement,　but　excessive　consumption　has　long-term　adverse　consequences.　A　high-salt　diet　(HSD)　increases　the　risk　of　chronic　diseases　such　as　cardiovascular　conditions　and　diabetes　and　is　also　associated　with　poor　sleep　quality.　Little　is　known,　however,　about　the　neural　circuit　mechanisms　that　mediate　HSD-induced　sleep　changes.　In　this　study,　we　sought　to　identify　the　effects　of　HSD　on　the　sleep　and　related　neural　circuit　mechanisms　of　Drosophila.　Strikingly,　we　found　that　HSD　causes　young　Drosophila　to　exhibit　a　fragmented　sleep　phenotype　similar　to　that　of　normal　aging　individuals.　Importantly,　we　further　showed　that　HSD　slightly　impairs　circadian　rhythms　and　that　the　HSD-induced　sleep　changes　are　dependent　on　the　circadian　rhythm　system.　In　addition,　we　demonstrated　that　HSD-induced　sleep　changes　are　dopaminergic-system　dependent.　Together,　these　results　provide　insight　into　how　elevated　salt　in　the　diet　can　affect　sleep　quality.　©　Copyright　©　2019　Xie,　Wang,　Ling,　Yang,　Yang　and　Chen.