This　work　explores　the　novel　one-pot　aqueous　phase　synthesis　of　mesoporous　phenolic-hyperbranched　polyethyleneimine　resins　without　the　use　of　a　template,　and　their　utility　as　heterogeneous　catalysts　in　batch　reactors　and　continuous　microreactors.　Catalyst　surface　areas　of　up　to　432　m2/g　were　achieved　with　a　uniform　Pd　distribution　and　an　interconnected,　highly　porous,　network　structure,　confirmed　through　Brunauer–Emmett–Teller　(BET)　surface　area　measurements,　scanning　electron　microscopes　(SEM),　X-Ray　Photoelectron　Spectroscopy　(XPS),　Transmission　Electron　Microscopy　(TEM),　and　Energy-dispersive　X-ray　spectroscopy　(EDS).　The　heterogeneous　catalysts　achieved　a　maximum　98.98　±　1%　conversion　in　batch　Suzuki　couplings,　with　conversions　being　dependent　upon　reaction　conditions,　reactant　chemistries,　Pd　loading　and　catalyst　surface　area.　The　catalysts　were　shown　to　be　recyclable　with　only　a　marginal　loss　in　conversion　achieved　after　five　runs.　Up　to　62　±　5%　and　46.5　±　8%　conversions　at　0.2　mL/s　and　0.4　mL/s　flow　rates,　respectively,　were　achieved　in　a　continuous　microreactor.　Understanding　the　mechanism　of　action　of　this　mesoporous　resin　is　a　future　research　area,　which　could　help　expand　the　application　vistas　for　this　catalyst　platform.　©　2019　by　the　authors.　Licensee　MDPI,　Basel,　Switzerland.