In　this　study,　approaches　to　improve　chiral　resolutions　in　simultaneous　enantioseparation　of　β-agonists　by　CE　via　a　CD　inclusion　complexation　modified　with　ionic　liquids　(ILs)　are　described.　Different　types　of　ILs,　including　tetraalkylammonium-based　ILs,　alkylimidazolium-based　ILs　and　alkylpyridinium-based　ILs,　were　examined　and　compared　for　controlling　the　EOF　in　order　to　improve　resolutions　of　β-agonists　enantiomers.　In　this　regard,　tetraalkylammonium-based　ILs　were　more　effective　because　they　could　be　used　at　much　higher　concentrations　than　other　types　of　ILs.　N-octylpyridinium　hexafluorophosphate　gave　poor　resolutions　of　β-agonists　enantiomers.　In　addition,　when　different　ILs　were　mixed　to　use,　they　would　present　particular　properties　of　their　own.　Moreover,　the　presence　of　ILs　was　essential　in　the　chiral　separations　of　(±)　salbutamol,　(±)　cimaterol　and　(±)　formoterol,　which　were　reportedly　not　enantioseparated　by　using　the　buffer　electrolytes　containing　only　β-CD　as　a　chiral　selector.　©　2009　Wiley-VCH　Verlag　GmbH　&　Co.　KGaA,　Weinheim.