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author:

Jiang, J. (Jiang, J..) [1] | Wu, Q.J. (Wu, Q.J..) [2] | Cai, X.Y. (Cai, X.Y..) [3] | Zhu, L.G. (Zhu, L.G..) [4] | Wang, W.J. (Wang, W.J..) [5]

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Scopus CSCD

Abstract:

The electrospray ionization mass spectrometry investigation showed that the binding sites of [ZnL]2+, where L is 2-[bis(2-aminoethyl)amino]ethanol, with oxidized insulin B chain are Phe1, His5 and Arg22, which lead to the selective cleavages of the peptide bonds at Phe1-Val2, His5-Leu6, Glu21-Arg22, and Arg22-Gly23 of oxidized insulin B chain. © 2008 Wen Ji Wang.

Keyword:

Hydrolytic cleavage; Mass spectrometry; Oxidized insulin B chain; Zn(II) complex

Community:

  • [ 1 ] [Jiang, J.]College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, 350002, China
  • [ 2 ] [Jiang, J.]College of Life Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, China
  • [ 3 ] [Wu, Q.J.]College of Life Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, China
  • [ 4 ] [Cai, X.Y.]College of Life Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, China
  • [ 5 ] [Zhu, L.G.]State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing, 210093, China
  • [ 6 ] [Wang, W.J.]College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, 350002, China

Reprint 's Address:

  • [Wang, W.J.]College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, 350002, China

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Source :

Chinese Chemical Letters

ISSN: 1001-8417

Year: 2009

Issue: 1

Volume: 20

Page: 71-75

0 . 6 4 3

JCR@2009

9 . 4 0 0

JCR@2023

JCR Journal Grade:3

CAS Journal Grade:1

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count: 1

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 1

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