Synthesis of metal phthalocyanines containing piperidine and their photoinhibition on cancer cell - Details

author：

Huang, Z.-Y. (Huang, Z.-Y..) ^[1] | Xue, J.-P. (Xue, J.-P..) ^[2] | Chen, J.-C. (Chen, J.-C..) ^[3] | Chen, N.-S. (Chen, N.-S..) ^[4] | Huang, J.-L. (Huang, J.-L..) ^[5]

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Abstract：

＇The　template　approach＇　was　used　for　the　synthesis　of　eight　metal　phthalocyanine　complexes　containing　piperidine　group　(PEO)4PcM,　where　M　=　Zn,　Ni,　Co,　Cu,　PEO　=　2-(piperidin-l-yl)　ethyoxyl.　These　complexes　were　characterized　by　FTIR,　mass　spectrum,　elemental　analysis　and　so　on.　The　UV-Vis　absorption　spectra,　fluorescence　emission　spectra　and　capacity　of　photo-generating　singlet　oxygen　were　examined.　The　results　showed　that　two　zinc　phthalocyanine　complexes　possessed　high　molar　extinction　coefficient,　fluorescence　quantum　yield,　high　rate　of　photo-generating　singlet　oxygen.　The　complex　with　formula　β-(PEO)4PcZn　had　a　photoinhibition　effect　to　BEL7402　liver　cancer　cells　up　to　83%　in　case　that　the　irradiation　with　670　nm　laser　light　(dosage　1.2　J)　and　the　concentration　of　β-(PEO)4PcZn　with　10μmol/L　were　used.

Keyword：

Metal phthalocyanine; N-Piperidineethanol; Photoinhibition; Synthesis

Community：

[ 1 ] [Huang, Z.-Y.]Institute on Research of Functional Materials, Fuzhou University, Fuzhou 350002, China
[ 2 ] [Huang, Z.-Y.]College of Chemistry and Materials Science, Fujian Normal University, Fuzhou 350007, China
[ 3 ] [Xue, J.-P.]Institute on Research of Functional Materials, Fuzhou University, Fuzhou 350002, China
[ 4 ] [Chen, J.-C.]Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China
[ 5 ] [Chen, N.-S.]Institute on Research of Functional Materials, Fuzhou University, Fuzhou 350002, China
[ 6 ] [Huang, J.-L.]Institute on Research of Functional Materials, Fuzhou University, Fuzhou 350002, China

Reprint 's Address：

[Huang, Z.-Y.]Institute on Research of Functional Materials, Fuzhou University, Fuzhou 350002, China

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Source ：

Chemical Journal of Chinese Universities

ISSN： 0251-0790

Year： 2008

Issue： 3

Volume： 29

Page： 445-448

0 . 5 9 2

JCR@2008

0 . 7 0 0

JCR@2023

JCR Journal Grade：3

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ESI Highly Cited Papers on the List： 0 Unfold All

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