A　monitoring　process　using　macroprogram(　in　SIM　mode)　to　accelerate　screening　analysis　of　diuretics　in　human　urine　with　subsequent　confirmation　by　SCAN　mode　was　established　for　improving　their　analysis　efficiency.　Microwave　assisted　derivatization　was　adopted　for　acceletating　pretreatment　speed.　Nine　kinds　of　diuretics　in　human　urine　were　quantitativly　detected　by　GC-MS　with　selected　ion　monitoring　technique.　The　detection　limit　of　these　diuretics　was　0.　3　-6.6　(xg/L,　the　average　recovery　was　37.　6%　-　96.　8%　and　the　RSD＜9.7%.　Using　of　advanced　microwave　assisted　derivatization　pretreatment　technique　and　macroprogram　data　processing　method,　the　analysis　time　decreased　for　3　h　and　sensitivity　completely　satisfied　for　WADA.　This　method　was　also　successfully　applied　to　identify　the　indapamide　positive　urine,　and　the　excretion　curve　of　indapamide　in　human　urine　was　described.