Metal phthalocyanines piperazine containing: Synthesis and photoinhibition on cancer cell - Details

author：

Huang, Z.-Y. (Huang, Z.-Y..) ^[1] | Huang, J.-D. (Huang, J.-D..) ^[2] | Chen, J.-C. (Chen, J.-C..) ^[3] | Chen, N.-S. (Chen, N.-S..) ^[4] | Huang, J.-L. (Huang, J.-L..) ^[5]

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Scopus PKU CSCD

Abstract：

The　synthesis　and　characterizations　of　eight　metal　phthalocyanines　containing　piperazine　(SPEO)4PcM,　where　M=Zn,　Ni,　Co　or　Cu,　SPEO　=2-[4-(2-sulfonic　ethyl)　piperazine-1-yl]　ethyoxyl　were　studied.　The　UV-Vis　absorption　spectra,　fluorescence　emission　spectra　and　capacity　of　singlet　oxygen　yield　with　DPBF　as　capturer　were　examined.　The　results　show　that　all　complexes　possess　very　high　molar　extinction　coefficient,　fluorescence　quantum　yield,　rate　of　singlet　oxygen　yield.　Zinc　phthalocyanine　complex　β-(SPEO)　4PcZn　possesses　the　best　photoinhibition　through　photodynamic　inhibition　of　BEL7402　liver　cancer　cells,　82%　cancer　cells　are　inhibited　after　it　is　irradiated　by　1.2　J　photo　dosage　of　670　nm　red-light　laser　when　the　concentration　of　β-(SPEO)4PcZn　with　10　μmol·　L-1　is　used.

Keyword：

HEPES; Metallophthalocyanine; Photoinhibition; Synthesis

Community：

[ 1 ] [Huang, Z.-Y.]Institute on Research of Functional Materials, Fuzhou University, Fuzhou 350002, China
[ 2 ] [Huang, Z.-Y.]College of Chemistry and Materials Science, Fujian Normal University, Fuzhou 350007, China
[ 3 ] [Huang, J.-D.]Institute on Research of Functional Materials, Fuzhou University, Fuzhou 350002, China
[ 4 ] [Chen, J.-C.]Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China
[ 5 ] [Chen, N.-S.]Institute on Research of Functional Materials, Fuzhou University, Fuzhou 350002, China
[ 6 ] [Huang, J.-L.]Institute on Research of Functional Materials, Fuzhou University, Fuzhou 350002, China

Reprint 's Address：

[Huang, Z.-Y.]Institute on Research of Functional Materials, Fuzhou University, Fuzhou 350002, China

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Source ：

Chinese Journal of Inorganic Chemistry

ISSN： 1001-4861

Year： 2008

Issue： 1

Volume： 24

Page： 55-60

0 . 5 3 2

JCR@2008

0 . 8 0 0

JCR@2023

JCR Journal Grade：4

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ESI Highly Cited Papers on the List： 0 Unfold All

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30 Days PV： 2

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