In　this　work,　a　novel　fluorescent　chemosensor,　based　on　a　polyether　bridged　squaraine,　has　been　developed　for　the　detection　of　Pb2+,　and　gives　excellent　sensitivity　and　selectivity　using　a　cation-induced　disaggregation　strategy.　This　probe　exhibited　a　specific　“turn　on”　fluorescent　response　to　Pb2+　with　a　detection　limit　of　1.70　×　10−8　M,　and　the　identification　for　Pb2+　was　not　impacted　by　competing　ions　such　as　Na+,　Li+,　K+,　Mg2+,　Ca2+,　Sr2+,　Co2+,　Ni2+,　Zn2+,　Ag+,　Cd2+,　and　Hg2+.　Due　to　the　high　binding　ability　of　the　polyether　bridged　ionophore　toward　Pb2+,　the　disaggregation　process　could　be　trigged　by　the　formation　of　squaraine-Pb2+　complex,　resulting　in　a　fast　fluorescent　release.　The　sensing　mechanism　has　been　confirmed　by　NMR,　IR,　and　dynamic　light　scattering　experiments.　Further　research　shows　that　this　novel　fluorescent　probe　can　be　applied　in　the　fast　detection　of　Pb2+　in　urine　and　shrimp　samples.　©　2016　Elsevier　B.V.