Artificial　enzyme　mimetics　have　received　considerable　attention　because　natural　enzymes　have　some　significant　drawbacks,　including　enzyme　autolysis,　low　catalytic　activity,　poor　recovery,　and　low　stability　to　environmental　changes.　Herein,　we　demonstrated　a　facile　approach　for　one-pot　synthesis　of　hemeprotein-metal　organic　framework　hybrid　composites　(H-MOFs)　by　using　bovine　hemoglobin　(BHb)　and　zeolitic　imidazolate　framework-8　(ZIF-8)　as　a　model　reaction　system.　Surprisingly,　the　new　hybrid　composites　exhibit　423%　increase　in　peroxidase-like　catalytic　activity　compared　to　free　BHb.　Taking　advantages　of　the　unique　pore　structure　of　H-MOFs　with　high　catalytic　property,　a　H-MOFs-based　colorimetric　biosensing　platform　was　newly　constructed　and　applied　for　the　fast　and　sensitive　detection　of　hydrogen　peroxide　(H2O2)　and　phenol.　The　corresponding　detection　limits　as　low　as　1.0　μM　for　each　analyte　with　wide　linear　ranges　(0-800　μM　for　H2O2　and　0-200　μM　for　phenol)　were　obtained　by　naked-eye　visualization.　Significantly,　a　sensitive　and　selective　method　for　visual　assay　of　trace　H2O2　in　cells　and　phenol　in　sewage　was　achieved　with　this　platform.　The　stability　of　H-MOFs　was　also　examined,　and　excellent　reproducibility　and　recyclability　without　losing　in　their　activity　were　observed.　In　addition,　the　general　applicability　of　H-MOFs　was　also　investigated　by　using　other　hemeproteins　(horseradish　peroxidase,　and　myoglobin),　and　the　corresponding　catalytic　activities　were　291%　and　273%　enhancement,　respectively.　This　present　work　not　only　expands　the　application　of　MOFs　but　also　provides　an　alternative　technique　for　biological　and　environmental　sample　assay.　©　2016　American　Chemical　Society.