Wind-resistant　in　isolation　layer　is　a　design　challenge　if　basic　wind　pressure　of　the　isolated　structure　is　relatively　large.　The　program　of　setting　steel　plate　wind-resistant　support　of　variable　stiffness　on　the　isolation　layer　is　proposed　to　reduce　the　number　of　the　lead-rubber　support　and　improve　the　damping　effect.　Based　on　practical　engineering　background,　the　horizontal　damping　coefficients　are　set　less　than　0.53,　0.40　and　0.27,　respectively,　to　establish　three　contrast　structure　models　and　make　time-history　analyses.　The　result　shows　that,　the　isolation　layer　form　combined　with　rubber　isolation　support　and　steel　plate　wind-resistant　support　of　variable　stiffness　is　reasonable　to　reduce　the　seismic　response,　improve　the　isolation　effect　and　meet　the　wind-resistant　design　objective.　However,　the　number　of　the　rubber　isolation　support　and　the　wind-resistant　support　requires　optimization　design.　Furthermore,　to　ensure　the　normal　use　of　the　structure,　it　is　proposed　that　the　lead　support　horizontal　design　value　is　close　to　the　isolation　layer　horizontal　shear　standard　value　under　wind　load.　The　working　mechanism　of　the　wind-resistant　support　of　variable　stiffness　is　clarified　by　conducting　structural　simulation　and　static　loading　shear　test　over　wind-resistant　support.　The　result　shows　that　the　wind-resistant　support　works　well　and　provides　horizontal　support　under　normal　working　conditions　and　small　earthquakes.　When　suffering　moderate　earthquakes,　the　wind-resistant　support　will　yield　and　be　destroyed　before　stopping　working,　making　the　damping　effect　unchangeable.　©　2016,　Nanjing　Univ.　of　Aeronautics　an　Astronautics.　All　right　reserved.