In　order　to　uncover　the　intrinsic　influence　of　mechanical　activation　on　property　of　oxidation　and　spontaneous　combustion　of　sulfide　ores,　the　thermal　analysis　technique　was　used　to　characterize　the　kinetic　parameters　of　samples　under　different　mechanical　powers　(100-450　r/min)　and　different　material-ball　ratios　(1:3-1:12)　after　mechanical　activation.　Meanwhile,　the　X-ray　diffraction　analysis　was　used　to　obtain　the　lattice　distortion　rate　and　block　size　after　mechanical　activation.　The　results　show　that　the　kinetics　reaction　process　of　the　sample　complies　with　the　diffusion　one-way　transport　mechanism　under　the　temperature　between　530　to　640℃.　By　the　increase　of　mechanical　power　and　material-ball　ratio,　the　apparent　activation　energy　of　samples　reduces　with　good　consistency.　The　corresponding　activation　energy　values　calculated　under　non-activated,　200　r/min,　350　r/min　are　258.93,　181.34　and　150.97　kJ/mol.　and　the　pre-exponential　factors　are　2.35×1018,　1.45×1013　and　1.60×1011,　respectively.　Meanwhile,　the　corresponding　activation　energy　values　calculated　under　1:3,　1:8　are　240.57,　150.97　kJ/mol,　respectively,　and　the　pre-exponential　factors　are　1.58×1017,　1.60×1011,　respectively.　The　reduction　of　apparent　activation　energy　of　mechanically　activated　sulfide　ores　is　related　to　the　increasement　of　lattice　distortion　rate　and　reduction　of　the　block　size,　so,　it　can　lead　to　spontaneous　combustion　under　proper　environmental　conditions.　©　2016,　Science　Press.　All　right　reserved.