Stepwise iododesilylation and coupling reaction: A flexible route to 2,4-disubstituted-1H-pyrroles - Details

author：

Liu, J. (Liu, J..) ^[1] | Fu, N. (Fu, N..) ^[2] | Wei, C. (Wei, C..) ^[3] | Song, Z. (Song, Z..) ^[4]

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Scopus

Abstract：

In　this　study,　we　report　a　new　strategy　for　the　synthesis　of　2,4-disubstituted　pyrroles　using　a　stepwise　iododesilylation　and　palladium-catalysed　Suzuki　coupling　reaction　of　2,4-bis(trimethylsilyl)-1-t-Boc-1H-pyrrole　(2).　The　regioselective　iodo-desilylation　followed　by　the　Suzuki　coupling　reaction　with　concomitant　Boc　deprotection　are　critical　aspects　of　the　new　synthesis　method.　©　2016　Elsevier　Ltd.　All　rights　reserved.

Keyword：

2,4-Disubstituted pyrroles; Iododesilylation; Suzuki coupling reaction; TMS-migration

Community：

[ 1 ] [Liu, J.]State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, 116024, China
[ 2 ] [Liu, J.]School of Petroleum and Chemical Engineering, Dalian University of Technology, Panjin Campus, Panjin, Liaoning Province, 124221, China
[ 3 ] [Fu, N.]Department of Chemistry, Fuzhou University, Fuzhou, Fujian, 350116, China
[ 4 ] [Wei, C.]State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, 116024, China
[ 5 ] [Song, Z.]State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, 116024, China

Reprint 's Address：

[Liu, J.]State Key Laboratory of Fine Chemicals, Dalian University of TechnologyChina

Email：

liujh@dlut.edu.cn

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Source ：

Tetrahedron Letters

ISSN： 0040-4039

Year： 2016

Issue： 23

Volume： 57

Page： 2530-2532

2 . 1 9 3

JCR@2016

1 . 5 0 0

JCR@2023

ESI HC Threshold：235

JCR Journal Grade：2

CAS Journal Grade：3

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ESI Highly Cited Papers on the List： 0 Unfold All

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30 Days PV： 0

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