We　develop　a　bimetallic　Pd-Cu　catalyst　that　takes　the　advantage　of　Pd-Cu　bimetal　as　active　species　and　earth-abundant　bauxite　as　support.　The　bauxite　support　with　high　surface　area　was　obtained　by　hydrothermal　NaOH　aqueous　solution　treatment,　and　the　amount　of　Pd　is　fixed　to　a　low　concentration　of　0.5%　(weight　percentage)　by　incipient-wetness　impregnation　method.　Their　catalytic　activity　for　CO　oxidation　reaction　has　also　been　studied.　The　effect　of　different　Cu　loading　content　on　the　chemical-physical　properties　of　the　as-prepared　catalysts　is　investigated　in　detail.　It　is　found　that　the　dispersion　of　Pd　species　is　promoted　by　the　introduction　of　Cu　species;　and　both　Pd-Cu　interaction　and　metal　(Pd-Cu　bimetals)-support　(modified　bauxite　(MB)　interaction　are　modulated　by　varying　the　Cu　content.　Furthermore,　the　catalytic　activities　with　respect　to　the　catalytic　CO　oxidation　are　performed,　and　the　catalyst　loaded　with　0.5%　Pd　and　4%　Cu　(PdCu4/MB)　shows　the　highest　catalytic　activity.　It　is　believed　that　the　well　dispersion　of　Pd　and　Cu,　the　strong　interactions　between　the　metals　and　the　support　as　well　as　between　Pd　and　Cu　are　responsible　for　the　highest　catalytic　activity　of　PdCu4/MB.　Moreover,　it　can　be　concluded　from　the　CO-TPD　investigation　that　superior　abilities　in　adsorption　of　CO　and　extraction　of　oxygen　from　the　support　are　favor　for　high　catalytic　activity　of　PdCu4/MB　catalyst　in　CO　oxidation.　©　2017,　Chinese　Chemical　Society.　All　rights　reserved.