Efficient asymmetric biosynthesis of (: R)-(-)-epinephrine in hydrophilic ionic liquid-containing systems - Details

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Abstract：

The　strain　Acinetobacter　sp.　UN-16　with　adrenaline　dehydrogenase　could　catalyze　adrenalone　to　(R)-(-)-epinephrine.　For　the　asymmetric　biosynthesis　of　(R)-(-)-epinephrine　with　whole　cells　of　Acinetobacter　sp.　UN-16,　ten　different　hydrophilic　ionic　liquids　were　successfully　tested.　The　diverse　water-ionic　liquid　systems　showed　significant　but　different　influences　on　the　initial　reaction　rate,　yield,　and　reduction　activity.　Of　all　the　tested　ionic　liquids,　[HOOCEMIM]NO3　showed　good　biocompatibility,　moderately　increased　cell　membrane　permeability,　markedly　improved　reaction　efficiency　and　best　biotransformation　results.　©　The　Royal　Society　of　Chemistry2016.

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[ 1 ] [Xu, Z.]Key Laboratory of Biopharmaceutical, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 2 ] [Wu, Q.]Key Laboratory of Biopharmaceutical, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 3 ] [Yang, M.]Key Laboratory of Biopharmaceutical, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 4 ] [Wang, S.]Key Laboratory of Biopharmaceutical, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 5 ] [Wang, Z.]Key Laboratory of Biopharmaceutical, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 6 ] [Xu, X.]Key Laboratory of Biopharmaceutical, College of Chemistry, Fuzhou University, Fuzhou, 350108, China

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[Xu, X.]Key Laboratory of Biopharmaceutical, College of Chemistry, Fuzhou UniversityChina

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xu@fzu.edu.cn

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RSC Advances

ISSN： 2046-2069

Year： 2016

Issue： 104

Volume： 6

Page： 102292-102295

3 . 1 0 8

JCR@2016

3 . 9 0 0

JCR@2023

ESI HC Threshold：235

JCR Journal Grade：2

CAS Journal Grade：3

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SCOPUS Cited Count： 6

ESI Highly Cited Papers on the List： 0 Unfold All

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30 Days PV： 0

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