Reactive　oxygen　species　are　products　of　cellular　metabolism　and　assigned　important　roles　in　biomedical　science　as　deleterious　factors　in　pathologies.　In　fact,　some　studies　have　shown　that　the　therapeutic　benefits　of　taking　antioxidants　were　limited　and　the　potential　for　therapeutic　intervention　remains　unclear.　New　evidences　showed　that　ROS　have　some　ability　of　intercellular　transportation.　For　treating　allergic　rhinitis,　as　a　novel　intracellular　superoxide　quencher,　TAT-SOD　applied　to　acupoints　LI　20　instead　of　directly　to　nasal　cavity　can　be　used　to　test　that.　TTA　group　apply　TAT-SOD　cream　prepared　by　adding　purified　TAT-SOD　to　the　vehicle　cream　to　acupoints　LI　20,　while　placebo　group　used　the　vehicle　cream　instead.　TTN　group　applied　the　same　TAT-SOD　cream　directly　to　nasal　cavity　three　times　daily.　Symptom　scores　were　recorded　at　baseline　and　days　8　and　15.　For　the　overall　efficacy　rate,　TTA　group　was　81.0%,　while　placebo　group　was　5.9%　and　TTN　was　0%.　Malondialdehyde　levels　decreased　observably　in　TTA　group,　and　superoxide　dismutase,　catalase,　and　glutathione　peroxidase　levels　remained　basically　unaffected.　Enzymatic　scavenging　of　the　intracellular　superoxide　at　acupoints　LI　20　proved　to　be　effective　in　treating　allergic　rhinitis,　while　no　improvement　was　observed　with　the　placebo　group　and　TTN　group.　©　2016　Jing-Ke　Guo　et　al.