Bone marrow stem cells response to collagen/single-wall carbon nanotubes-COOHs nanocomposite films with transforming growth factor beta 1 - Details

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Abstract：

Single-wall　carbon　nanotubes　(SWNTs)　have　attractive　biochemical　properties　such　as　strong　cell　adhesion　and　protein　absorption,　which　are　very　useful　for　a　cell　cultivation　scaffold.　In　this　study,　collagen/SWNT-COOHs　nanocomposite　films　composed　of　regenerated　fish　collagen　and　SWNTCOOHs　(0,　0.5,　1.0　and　2.0　weight　percent)　were　prepared　by　mixing　solubilized　pepsin-soluble　collagen　with　solutions　of　SWNT-COOHs.　Morphological　observation　by　SEM　indicated　the　homogenous　dispersion　of　SWNT-COOHs　in　the　collagen　matrix.　The　application　of　FTIR　confirmed　that　the　process　we　applied　to　prepare　the　composites　did　not　destroy　the　native　structures　of　collagen　and　composites　were　crosslinked　by　D-ribose.　The　biocompatibility　was　evaluated　in　vitro　using　SD　rat　bone　marrow　stem　cells　(BMSCs).　Compared　with　films　without　transforming　growth　factor　beta　1　(TGF-β1),　films　with　TGF-β　1　had　superior　performance　on　promotion　of　cell　growth.　Compared　with　pure　collagen　film　with　TGF-β-　1,　SWNT-containing　films　might　promote　cellular　functions　by　adsorbing　more　growth　factors.　In　conclusion,　the　study　suggested　that　the　collagen/SWNTCOOHs　nanocomposite　films　with　TGF-β1　were　expected　to　be　useful　scaffolds　in　cartilage　tissue　engineering.　Copyright　©　2015　American　Scientific　Publishers　All　rights　reserved.

Keyword：

Bone marrow stem cells; Carbon nanotubes; Cartilage tissue engineering; Collagen

Community：

[ 1 ] [Wang, J.]Institute of Biomedical and Pharmaceutical Technology, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, 350002, China
[ 2 ] [He, C.]Institute of Biomedical and Pharmaceutical Technology, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, 350002, China
[ 3 ] [Cheng, N.]Institute of Biomedical and Pharmaceutical Technology, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, 350002, China
[ 4 ] [Yang, Q.]Institute of Biomedical and Pharmaceutical Technology, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, 350002, China
[ 5 ] [Chen, M.]Institute of Biomedical and Pharmaceutical Technology, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, 350002, China
[ 6 ] [You, L.]Institute of Biomedical and Pharmaceutical Technology, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, 350002, China
[ 7 ] [Zhang, Q.]Institute of Biomedical and Pharmaceutical Technology, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, 350002, China
[ 8 ] [Zhang, Q.]Institute of Biomedical Engineering, Chinese Academy of Medical Science, Peking Union Medical College, Tianjin, 300192, China

Reprint 's Address：

[Zhang, Q.]Institute of Biomedical and Pharmaceutical Technology, College of Chemistry and Chemical Engineering, Fuzhou UniversityChina

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Source ：

Journal of Nanoscience and Nanotechnology

ISSN： 1533-4880

Year： 2015

Issue： 7

Volume： 15

Page： 4844-4850

1 . 3 3 8

JCR@2015

1 . 1 3 4

JCR@2019

JCR Journal Grade：3

CAS Journal Grade：4

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WoS CC Cited Count：

SCOPUS Cited Count： 24

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 7

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