• Complex
  • Title
  • Keyword
  • Abstract
  • Scholars
  • Journal
  • ISSN
  • Conference
成果搜索

author:

Li, H. (Li, H..) [1] | Ma, L. (Ma, L..) [2] | Li, X. (Li, X..) [3] | Cui, X. (Cui, X..) [4] | Yang, W. (Yang, W..) [5] | Shen, S. (Shen, S..) [6] | Chen, M. (Chen, M..) [7]

Indexed by:

Scopus

Abstract:

The purpose of this study was to improve the solubility and bioavailability of glimepiride (GLMP) by utilizing hydrotropy technique. Meglumine (MU) as a hydrotrope could form the stable complex with glimepiride. The optimal glimepiride and meglumine (GLMP-MU) complex powder was obtained by using lyophilization. GLMP-MU powder was characterized by Fourier transform infrared spectroscopy (FT IR), X-ray powder diffraction (XRD) and differential scanning calorimetry (DSC). The formation of hydrogen bond between glimepiride and meglumine was confirmed by FT IR. The XRD studies indicated the amorphous state of glimepiride was appeared in the GLMP-MU. The DSC results were further confirmed GLMP-MU complex was prepared successfully. Moreover, the in vitro drug release rate of GLMP-MU powder was dramatically faster than that of glimepiride. Meanwhile, the AUC of GLMP-MU solution at an i.g./or i.v. dose of 5 mg/kg in rat was significantly higher than that of the glimepiride suspensions. Together our results showed that hydrotropy technique was a simple and effective method to increase the solubility of glimepiride. © 2015 Elsevier B.V. All rights reserved.

Keyword:

Bioavailability; Complex; Glimepiride; Hydrotropy technique; Meglumine

Community:

  • [ 1 ] [Li, H.]College of Pharmacy, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding, 071002, China
  • [ 2 ] [Ma, L.]College of Pharmacy, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding, 071002, China
  • [ 3 ] [Li, X.]College of Pharmacy, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding, 071002, China
  • [ 4 ] [Cui, X.]College of Pharmacy, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding, 071002, China
  • [ 5 ] [Yang, W.]College of Pharmacy, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding, 071002, China
  • [ 6 ] [Shen, S.]College of Pharmacy, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding, 071002, China
  • [ 7 ] [Chen, M.]Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou, 350108, China

Reprint 's Address:

  • [Yang, W.]College of Pharmacy, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei UniversityChina

Email:

Show more details

Related Keywords:

Related Article:

Source :

European Journal of Pharmaceutical Sciences

ISSN: 0928-0987

Year: 2015

Volume: 77

Page: 154-160

3 . 7 7 3

JCR@2015

4 . 3 0 0

JCR@2023

ESI HC Threshold:193

JCR Journal Grade:1

CAS Journal Grade:2

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count: 27

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 2

Affiliated Colleges:

Online/Total:183/10018530
Address:FZU Library(No.2 Xuyuan Road, Fuzhou, Fujian, PRC Post Code:350116) Contact Us:0591-22865326
Copyright:FZU Library Technical Support:Beijing Aegean Software Co., Ltd. 闽ICP备05005463号-1