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author：

Li, J. (Li, J..) [1] | Zheng, C. (Zheng, C..) [2] | Cansiz, S. (Cansiz, S..) [3] | Wu, C. (Wu, C..) [4] | Xu, J. (Xu, J..) [5] | Cui, C. (Cui, C..) [6] | Liu, Y. (Liu, Y..) [7] | Hou, W. (Hou, W..) [8] | Wang, Y. (Wang, Y..) [9] | Zhang, L. (Zhang, L..) [10] | Teng, I.-T. (Teng, I.-T..) [11] | Yang, H.-H. (Yang, H.-H..) [12] | Tan, W. (Tan, W..) [13]

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Scopus

Abstract：

Here,　we　report　the　synthesis　and　characterization　of　size-controllable　and　stimuli-responsive　DNA　nanohydrogels　as　effective　targeted　gene　delivery　vectors.　DNA　nanohydrogels　were　created　through　a　self-assembly　process　using　three　kinds　of　building　units,　respectively　termed　Y-shaped　monomer　A　with　three　sticky　ends　(YMA),　Y-shaped　monomer　B　with　one　sticky　end　(YMB),　and　DNA　linker　(LK)　with　two　sticky　ends.　Hybridization　at　the　sticky　ends　of　monomers　and　LK　leads　to　nanohydrogel　formation.　DNA　nanohydrogels　are　size-controllable　by　varying　the　ratio　of　YMA　to　YMB.　By　incorporating　different　functional　elements,　such　as　aptamers,　disulfide　linkages,　and　therapeutic　genes　into　different　building　units,　the　synthesized　aptamer-based　nanohydrogels　(Y-gel-Apt)　can　be　used　for　targeted　and　stimuli-responsive　gene　therapy.　Y-gel-Apt　strongly　inhibited　cell　proliferation　and　migration　in　target　A549　cells,　but　not　in　control　cells.　By　taking　advantage　of　facile　modular　design　and　assembly,　efficient　cellular　uptake,　and　superior　biocompatibility,　this　Y-gel-Apt　holds　great　promise　as　a　candidate　for　targeted　gene　or　drug　delivery　and　cancer　therapy.　©　2015　American　Chemical　Society.

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  • [ 1 ] [Li, J.]Key Lab of Analysis and Detection Technology for Food Safety of the MOE, College of Chemistry, Fuzhou University, Fuzhou, 350002, China
  • [ 2 ] [Li, J.]Department of Chemistry and Physiology and Functional Genomics, Shands Cancer Center, University of Florida, Gainesville, FL 32611-7200, United States
  • [ 3 ] [Zheng, C.]Key Lab of Analysis and Detection Technology for Food Safety of the MOE, College of Chemistry, Fuzhou University, Fuzhou, 350002, China
  • [ 4 ] [Cansiz, S.]Department of Chemistry and Physiology and Functional Genomics, Shands Cancer Center, University of Florida, Gainesville, FL 32611-7200, United States
  • [ 5 ] [Wu, C.]Department of Chemistry and Physiology and Functional Genomics, Shands Cancer Center, University of Florida, Gainesville, FL 32611-7200, United States
  • [ 6 ] [Xu, J.]Department of Chemistry and Physiology and Functional Genomics, Shands Cancer Center, University of Florida, Gainesville, FL 32611-7200, United States
  • [ 7 ] [Xu, J.]Department of Nuclear Medicine, Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510630, China
  • [ 8 ] [Cui, C.]Department of Chemistry and Physiology and Functional Genomics, Shands Cancer Center, University of Florida, Gainesville, FL 32611-7200, United States
  • [ 9 ] [Liu, Y.]Department of Chemistry and Physiology and Functional Genomics, Shands Cancer Center, University of Florida, Gainesville, FL 32611-7200, United States
  • [ 10 ] [Hou, W.]Department of Chemistry and Physiology and Functional Genomics, Shands Cancer Center, University of Florida, Gainesville, FL 32611-7200, United States
  • [ 11 ] [Wang, Y.]Department of Chemistry and Physiology and Functional Genomics, Shands Cancer Center, University of Florida, Gainesville, FL 32611-7200, United States
  • [ 12 ] [Zhang, L.]Department of Chemistry and Physiology and Functional Genomics, Shands Cancer Center, University of Florida, Gainesville, FL 32611-7200, United States
  • [ 13 ] [Teng, I.-T.]Department of Chemistry and Physiology and Functional Genomics, Shands Cancer Center, University of Florida, Gainesville, FL 32611-7200, United States
  • [ 14 ] [Yang, H.-H.]Key Lab of Analysis and Detection Technology for Food Safety of the MOE, College of Chemistry, Fuzhou University, Fuzhou, 350002, China
  • [ 15 ] [Tan, W.]Molecular Science and Biomedicine Laboratory, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China
  • [ 16 ] [Tan, W.]Department of Chemistry and Physiology and Functional Genomics, Shands Cancer Center, University of Florida, Gainesville, FL 32611-7200, United States

Reprint 's Address：

  • [Yang, H.-H.]Key Lab of Analysis and Detection Technology for Food Safety of the MOE, College of Chemistry, Fuzhou UniversityChina

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Source ：

Journal of the American Chemical Society

ISSN： 0002-7863

Year： 2015

Issue： 4

Volume： 137

Page： 1412-1415

1 3 . 0 3 8

JCR@2015

1 4 . 5 0 0

JCR@2023

ESI HC Threshold：265

JCR Journal Grade：1

CAS Journal Grade：1

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count： 431

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 0

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