TiO2　nanostructures　have　been　considered　as　promising　anode　materials　in　a　new　generation　of　lithiumion　batteries　due　to　their　high　safety,　superior　rate　capability　and　excellent　cyclic　stability.　In　particular,　TiO2　mesocrystals,　a　new　class　of　superstructured　materials,　have　attracted　a　great　deal　of　research　interests　due　to　the　unique　structure　composed　of　crystallographically　oriented　nanocrystals,　and　thus　showed　improved　lithium-ion　insertion　performance.　In　this　review,　recent　progress　in　preparation　and　lithium-ion　storage　properties　of　TiO2　mesocrystals　are　summarized.　Two　typical　ways　for　synthesizing　TiO2　mesocrystals　are　described,　namely,　the　oriented　topotactic　transformation　and　direct　synthesis　in　solution.　The　additive-free　synthesis　of　TiO2　mesocrystals　and　their　lithium-ion　intercalation　properties　are　highlighted　and　discussed.　©　2015　The　Chemical　Society　Located　in　Taipei　&　Wiley-VCH　Verlag　GmbH　&　Co.　KGaA,　Weinheim,　Germany.