Based　on　a　previous　investigation,　a　simulation　model　was　used　for　optimization　of　coproduction　of　ethyl　acetate　and　n-butyl　acetate　by　reactive　distillation.　An　experimental　setup　was　established　to　verify　the　simulated　results.　The　effects　of　various　operating　variables,　such　as　ethanol　feed　location,　acetic　acid　feed　location,　feed　stage　of　reaction　mixture　of　acetic　acid　and　n-butanol,　reflux　ratio　of　ethyl　acetate　reactive　distillation　column,　and　distillate　to　feed　ratio　of　n-butyl　acetate　column,　on　the　ethanol/n-butanol　conversions,　ethyl　acetate/n-butyl　acetate　purity,　and　energy　consumption　were　investigated.　The　optimal　results　in　the　simulation　study　are　as　follows:　ethanol　feed　location,　15th　stage;　acetic　acid　feed　location,　eighth　stage;　feed　location　of　reaction　mixture　of　acetic　acid　and　n-butanol,　eighth　stage;　reflux　ratio　of　ethyl　acetate　reactive　distillation　column,　2.0;　and　distillate　to　feed　ratio　of　n-butyl　acetate,　0.6.　©　2014　The　Chemical　Industry　and　Engineering　Society　of　China,　and　Chemical　Industry　Press.　All　rights　reserved.