Previous　studies　suggest　that　superoxide　anions　are　possibly　traveling　along　acupuncture　meridians.　The　electrical　potential　difference　(EPD)　between　acupoints　may　be　related　to　the　movement.　To　test　the　above　hypothesis,　we　conducted　a　study　investigating　the　effects　of　acupoint　antioxidant　interventions　on　the　meridian　EPD.　Firstly,　ST39　(L)　and　ST44　(L)　were　screened　out　for　the　EPD　detection　along　the　stomach　meridian,　and　ST36　(L)　was　selected　for　interventions　including　acumassage　with　the　control　cream,　as　well　as　the　TAT-SOD　cream　for　30　minutes,　or　injection　with　reduced　glutathione　sodium.　The　EPD　between　ST39　and　ST44　was　recorded　for　80　minutes　and　measured　again　48　h　later.　While　the　EPD　increased　during　the　acumassage,　the　acumassage　with　TAT-SOD　cream　and　the　glutathione　injection　generated　waves　of　EPD　increased,　indicating　the　migration　or　removal　from　the　visceral　organ　of　a　greater　quantity　of　superoxide.　Remarkably　lower　EPD　readings　48　h　later　with　both　antioxidant　acupoint　interventions　than　the　mere　acumassage　imply　a　more　complete　superoxide　flushing　out　due　to　the　restored　superoxide　pathway　at　the　acupoint　after　interventions.　The　results　confirm　superoxide　transportation　along　the　meridians　and　demonstrate　a　possibility　of　acupoint　EPD　measurement　as　a　tool　to　monitor　changes　in　the　meridians　and　acupoints.　©　2015　Ming-Ming　Xu　et　al.