Four new penicitrinols and two new penicillenols from the marine-derived fungus Penicillium citrinum - Details

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Six　new　compounds,　penicitrinols　L-O　(1-4),　penicillenols　D1　(9)　and　D2　(10),　together　with　six　known　compounds　were　isolated　from　the　marine-derived　fungus　Penicillium　citrinum.　Their　structures　were　elucidated　on　the　basis　of　comprehensive　spectral　analysis　and　chemical　methods.　All　the　new　compounds　were　evaluated　for　their　cytotoxic　effects　on　the　A-549,　HL-60　and　SW-620　cell　lines　by　the　MTT　method.　Penicitrinols　L　(1)　and　M　(2)　showed　weak　cytotoxicities　against　SW-620　cell　line,　while　penicillenols　D1　(9)　and　D2　(10)　showed　weak　cytotoxicities　against　A-549　and　HL-60　cell　lines,　respectively.　©　2015　The　Japan　Institute　of　Heterocyclic　Chemistry.

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[ 1 ] [Chen, L.]Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou, 350002, China
[ 2 ] [Zhou, T.]Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou, 350002, China
[ 3 ] [Zhao, Y.-Y.]Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou, 350002, China
[ 4 ] [Gong, M.-W.]Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou, 350002, China
[ 5 ] [Xia, Q.-W.]Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou, 350002, China
[ 6 ] [Ying, M.-G.]Fujian Provincial Key Laboratory of Tumor Biotherapy, Fujian Provincial Tumor Hospital, Fuzhou, 350014, China
[ 7 ] [Zheng, Q.-H.]Fujian Provincial Key Laboratory of Tumor Biotherapy, Fujian Provincial Tumor Hospital, Fuzhou, 350014, China
[ 8 ] [Liu, Q.-Y.]Fujian Provincial Key Laboratory of Tumor Biotherapy, Fujian Provincial Tumor Hospital, Fuzhou, 350014, China
[ 9 ] [Zhang, Q.-Q.]Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou, 350002, China
[ 10 ] [Zhang, Q.-Q.]Institute of Biomedical Engineering, Chinese Academy of Medical Science, Peking Union Medical College, Tianjin, 300192, China

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[Chen, L.]Institute of Biomedical and Pharmaceutical Technology, Fuzhou UniversityChina

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Heterocycles

ISSN： 0385-5414

Year： 2015

Issue： 5

Volume： 91

Page： 1007-1016

1 . 1 0 7

JCR@2015

0 . 8 0 0

JCR@2023

ESI HC Threshold：265

JCR Journal Grade：3

CAS Journal Grade：4

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ESI Highly Cited Papers on the List： 0 Unfold All

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30 Days PV： 1

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