In　this　paper,　an　analysis　is　made　for　a　nanofluid　flow　in　a　porous　channel　by　introducing　the　conservation　equation　of　nanoparticle　volume　fraction　into　Tiwari　and　Das＇s　nanofluid　model.　The　suction　and　chemical　reaction　are　also　considered　in　this　work.　The　governing　partial　differential　equations　are　simplified　by　employing　a　new　variable　and　transformed　into　a　system　of　high-order　nonlinear　ordinary　differential　equations　by　similarity　transformations.　The　Keller　box　method　is　used　to　solve　this　problem　numerically.　In　addition,　the　influences　of　significant　physical　parameters　on　the　distributions　of　the　velocity　and　temperature　as　well　as　nanoparticle　concentration　are　graphically　presented　and　discussed　in　detail.　It　is　found　that　there　exists　a　critical　value　of　the　permeable　parameter　which　determines　the　influence　law　of　nanoparticle　volume　fraction　parameter　on　skin　friction　coefficient　and　local　Sherwood　number.　The　results　also　indicate　that　the　concentration　increases　sharply　with　the　Schmidt　number　and　chemical　reaction　parameter.　©　2016　Wiley　Periodicals,　Inc.