This　study　herein　develops　a　novel　tumor-targeting　photothermal　heating-responsive　nanoplatform　for　enhanced　photodynamic　therapy　(PDT).　The　nanoplatform　is　prepared　by　using　dopamine-reduced　graphene　oxide　nanosheets　(rGO-PDA)　to　enhance　photothermal　ability,　mesoporous　silica　coated　on　the　rGO-PDA　surface　to　load　drug,　and　hyaluronic　acid　to　act　as　gate　keeper　as　well　as　targeting　moiety.　The　developed　nanoplatform　has　outstanding　biocompatibility,　well　targeting　ability,　excellent　near-infrared　radiation　(NIR)　photothermal　conversion　ability,　controllable　drug　release　with　NIR　irradiation　response,　and　the　capacity　of　delivering　diverse　drugs.　The　proposed　nanoplatform　is　successfully　used　to　specifically　deliver　chlorin　e6　(Ce6)　to　CD-44　over-expressing　cancer　cells　for　PDT　with　a　loading　capacity　of　0.605　mg　mg−1　and　controllable　Ce6　release　with　NIR　irradiation　response.　The　combination　of　excellent　NIR　photothermal　conversion　ability　and　controllable　Ce6　release　confers　the　nanoplatform　with　enhanced　singlet　oxygen　generation,　which　leads　to　more　significant　destruction　of　target　cancer　cells.　The　prepared　photothermal　heating-responsive　nanoplatform　can　enhance　photodynamic　therapeutic　efficiency　and　hold　great　potential　for　multimodal　cancer　therapy.　©　2017　WILEY-VCH　Verlag　GmbH　&　Co.　KGaA,　Weinheim