Au@Pt nanoparticles as catalase mimics to attenuate tumor hypoxia and enhance immune cell-mediated cytotoxicity - Details

author：

Liang, H. (Liang, H..) ^[1] | Wu, Y. (Wu, Y..) ^[2] | Ou, X.-Y. (Ou, X.-Y..) ^[3] | Li, J.-Y. (Li, J.-Y..) ^[4] | Li, J. (Li, J..) ^[5]

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Abstract：

Hypoxic　tumor　microenvironment　(TME)　is　closely　linked　to　tumor　progression,　heterogeneity　and　immune　suppression.　Therefore,　the　development　of　effective　methods　to　overcome　hypoxia　and　substantially　enhance　the　immunotherapy　efficacy　remains　a　desirable　goal.　Herein,　we　engineered　a　biocompatible　Au　core/Pt　shell　nanoparticles　(Au@Pt　NPs)　to　reoxygenate　the　TME　by　reacting　with　endogenous　H2O2.　Treatment　with　Au@Pt　NPs　appeared　to　improve　oxygen　in　intracellular　environments　and　decrease　hypoxia-inducible　factor-1μ　expression.　Furthermore,　the　integration　of　high　catalytic　efficiency　of　Au@Pt　NPs　with　cytokine-induced　killer　(CIK)　cell　immunotherapy,　could　lead　to　significantly　improve　the　effect　of　CIK　cell-mediated　cytotoxicity.　These　results　suggest　great　potential　of　Au@Pt　NPs　for　regulation　of　the　hypoxic　TME　and　enhance　immune　cell　mediated　anti-tumor　immunity.　©　2017　IOP　Publishing　Ltd.

Keyword：

catalase mimics; hypoxia; immune cell-mediated cytotoxicity; nanoparticle

Community：

[ 1 ] [Liang, H.]MOE, Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350002, China
[ 2 ] [Wu, Y.]MOE, Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350002, China
[ 3 ] [Ou, X.-Y.]MOE, Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350002, China
[ 4 ] [Li, J.-Y.]College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350116, China
[ 5 ] [Li, J.]MOE, Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350002, China

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Source ：

Nanotechnology

ISSN： 0957-4484

Year： 2017

Issue： 46

Volume： 28

3 . 4 0 4

JCR@2017

2 . 9 0 0

JCR@2023

ESI HC Threshold：306

JCR Journal Grade：1

CAS Journal Grade：3

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SCOPUS Cited Count：

ESI Highly Cited Papers on the List： 0 Unfold All

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30 Days PV： 3

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