Lithium-sulfur　(Li-S)　batteries　are　receiving　much　attention　due　to　their　high　theoretical　lithium　storage　capacity　and　energy　density.　However,　the　commercialization　of　Li-S　batteries　is　mainly　impeded　by　the　inherent　poor　electrical　conductivity　of　sulfur,　the　side　shuttle　behavior　of　polysulfides,　and　the　volumetric　change　of　sulfur　during　cycles.　To　solve　these　problems,　here　we　report　a　unique　3D　porous　and　interconnected　hollow　carbon　nanospheres　array　(3D-HCNA)　as　sulfur　host　for　lithium-sulfur　batteries.　This　3D-HCNA　was　synthesized　through　a　nanocasting　approach　with　sucrose　as　carbon　precursors　and　mesoporous　silica　nanospheres　as　hard-templates.　The　silica　nanospheres　with　special　nanostructure　were　obtained　by　a　biphase　stratification　approach.　Owing　to　its　unique　architecture,　as-prepared　3D-HCNA/S　cathode　with　a　high　sulfur　loading　of　76　wt%　exhibited　excellent　electrochemical　performance.　It　showed　high　initial　capacity　of　1318　mAh/g　at　0.05　C　and　good　rate　capability　of　760　mAh/g　at　1　C.　Moreover,　excellent　cycling　performance　was　also　observed　with　a　capacity　of　757　mAh/g　maintained　after　200　cycles　at　0.5　C.