Magnetic　fluid　hyperthermia　can　ablate　malignant　cells　by　using　heat　from　magnetic　nanoparticles　(MNPs)　when　subjected　to　an　alternating　magnetic　field.　In　comparison　with　other　types　of　MNPs,　the　ones　with　low　Curie　temperature　(LCT)　have　the　characteristic　of　temperature　self-regulation,　which　contributes　to　its　choice　for　hyperthermia　therapy.　To　validate　the　advantages　of　LCT　MNPs　over　MNPs　with　high　Curie　temperature,　this　paper　proposes　a　complex　geometric　model　based　on　the　prototype　of　a　human　liver,　in　which　blood　vessels　(BVs)　and　nanoparticle　clustering　are　considered.　In　this　paper,　the　temperature　fields　of　tumor　tissue　with　different　MNPs　are　predicted　by　solving　the　Pennes　bioheat　transfer　equation,　while　the　effect　of　BVs　is　taken　into　account　by　solving　the　Navier-Stokes　equation.　Simulation　results　demonstrate　that　MNP　systems　with　LCT　can　have　better　therapeutic　effect　than　the　Fe　3　O　4　MNPs　if　the　power　dissipation　is　increased　with　respect　to　its　critical　value.　Higher　thermal　energy　absorbing　from　magnetic　field　not　only　increases　the　uniformity　of　the　temperature　field,　but　also　can　shorten　the　startup　time　in　MNP　systems　with　LCT,　which　does　not　occur　in　Fe　3　O　4　MNPs　systems.　Such　advantages　of　LCT　MNPs　are　observed　for　minimizing　the　undesirable　effects　of　both　BVs　and　MNP　clustering.　©　1965-2012　IEEE.