We　report　here　a　novel　synergistic　catalysis　system　combined　with　porous　organic　polymeric　solid　acid　(H-PDVB-SO3H)　and　K2O　doped　porous　γ-Al2O3　solid　base　(γ-Al2O3-K2O).　H-PDVB-SO3H　and　γ-Al2O3-K2O　have　abundant　nanopores,　controllable　surface　wettability,　and　high　concentrations　of　acidic　and　basic　sites.　The　synergistic　catalysis　system　exploited　by　us　could　efficiently　transform　acidulated　bone　oil　and　plant　oil　into　high　quality　biodiesel　under　mild　conditions,　which　achieved　ASTM　specifications　pertaining　to　acid　number　and　total　and　free　glycerin.　Acidulated　bone　is　a　bone　meal　treated　with　sulfuric　acid　containing　high-value　hydrocarbons,　which　is　generated　in　large　amounts　by　the　cattle　industry.　This　work　develops　an　efficient　and　cost-effective　approach　to　transform　animal　waste　into　high　quality　biodiesel.　©　2017　American　Chemical　Society.