A　new　signal　amplified　protocol　for　sensitive　monitor　of　ochratoxin　A　was　developed　by　coupling　platinum　enhancement　technique　to　a　redox　cycling　amplification　strategy.　Initially,　platinum-enclosed　gold　cores　(AuPtNP)　were　functionalized　with　monoconal　antibody　against　ochratoxin　A　(OTA)　to　act　as　signal　tags.　Upon　addition　of　analyte　(OTA),　competitive　immunobinding　occurs　between　OTA　and　an　OTA-BSA　conjugate　immobilized　on　a　ferrocene　modified　electrode　for　the　anti-OTA　on　the　signal　tags.　Next,　the　AuPtNPs　on　the　immunosensor　are　incubated　with　a　platinum　enhancing　solution　to　initiate　the　growth　of　additional　catalysts　in　order　to　further　promote　the　catalytic　cycling　between　p-aminophenol　and　p-quinoneimine　with　the　aid　of　the　reductant　NaBH4　and　ferrocene.　As　a　result,　the　analytical　signal　is　strongly　enhanced　and　can　be　measured　by　differential　pulse　voltammetry　in　the　range　from　−300 mV　to　600 mV　(vs.　SCE)　at　50 mV　s−1.　Under　optimized　conditions,　the　immunosensor　displays　a　dynamic　working　range　that　extends　from　0.2 pg⋅mL−1　to　5 ng⋅mL−1　of　OTA,　with　a　lower　detection　limit　of　75 fg⋅mL−1.　The　method　is　highly　selective　and　was　applied　to　the　determination　of　OTA　in　(spiked)　red　wine　samples.　©　2017,　Springer-Verlag　Wien.