One-pot synthesis of tricyclo-1,4-benzoxazines via visible-light photoredox catalysis in continuous flow - Details

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Abstract：

A　facile　one-pot　synthesis　of　tricyclo-1,4-benzoxazines　has　been　developed　via　metal-free　intramolecular　cyclization　of　indole　derivates.　These　reactions　were　efficiently　achieved　at　ambient　temperature　by　using　visible-light　photoredox　catalysis　in　continuous　flow.　This　directed　intramolecular　cyclization　could　be　easily　handled　and　scaled　up　in　an　open　flask,　enabling　construction　of　a　focused　compound　library　for　further　pharmacological　evaluation.　©　2017　Elsevier　Ltd

Keyword：

Flow chemistry; Intramolecular cyclization; Metal-free; One-pot; Room temperature

Community：

[ 1 ] [Wu, G.]College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China
[ 2 ] [Lv, T.]College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China
[ 3 ] [Mo, W.]College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China
[ 4 ] [Yang, X.]College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China
[ 5 ] [Gao, Y.]College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China
[ 6 ] [Chen, H.]College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China

Reprint 's Address：

[Chen, H.]College of Chemistry, Fuzhou UniversityChina

Email：

chenhaij@gmail.com

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Source ：

Tetrahedron Letters

ISSN： 0040-4039

Year： 2017

Issue： 14

Volume： 58

Page： 1395-1398

2 . 1 2 5

JCR@2017

1 . 5 0 0

JCR@2023

ESI HC Threshold：226

JCR Journal Grade：2

CAS Journal Grade：4

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SCOPUS Cited Count：

ESI Highly Cited Papers on the List： 0 Unfold All

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Chinese Cited Count：

30 Days PV： 1

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