Folic acid-conjugated Fe 3 O 4 magnetic nanoparticles for hyperthermia and MRI in vitro and in vivo - Details

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Abstract：

The　folic　acid　(FA)-conjugated　Fe　3　O　4　magnetic　nanoparticles　(MNPs)　were　synthesized　by　co-precipitation　of　Fe　3+　and　Fe　2+　solution　followed　by　surface　modification　with　carboxymethyl　dextran　(CMD)　to　form　carboxymethyl　group　terminated　MNPs,　then　FA　was　conjugated　with　the　carboxyl　group　functionalized　MNPs.　The　morphology　and　properties　of　obtained　nanoparticles　were　characterized　by　X-ray　powder　diffraction　(XRD),　Fourier　transform　infrared　spectroscopy　(FT-IR),　UV-visible　spectra　(UV-vis),　transmission　electron　microscopy　(TEM),　dynamic　light　scattering　(DLS),　vibrating　sample　magnetometer　(VSM)　and　thermogravimetric　analysis　(TGA).　The　FA-conjugated　MNPs　exhibited　relatively　high　saturation　magnetization　and　fast　magneto-temperature　response　which　could　be　applied　to　hyperthermia　therapy.　To　determine　the　accurate　targeting　effect　of　FA,　we　chose　FA-conjugated　MNPs　as　MRI　contrast　enhancement　agent　for　detection　of　KB　cells　with　folate　receptor　over-expression　in　vitro　and　in　vivo.　The　results　show　that　these　magnetic　nanoparticles　appear　to　be　the　promising　materials　for　local　hyperthermia　and　MRI.　©　2014　Published　by　Elsevier　B.V.

Keyword：

Folic acid; Hyperthermia; MRI

Community：

[ 1 ] [Jiang, Q.L.]College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Organic Synthesis of Jiangsu Province, Soochow University, Suzhou 215123, China
[ 2 ] [Zheng, S.W.]College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Organic Synthesis of Jiangsu Province, Soochow University, Suzhou 215123, China
[ 3 ] [Hong, R.Y.]College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Organic Synthesis of Jiangsu Province, Soochow University, Suzhou 215123, China
[ 4 ] [Hong, R.Y.]College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002, China
[ 5 ] [Deng, S.M.]First Affiliated Hospital of Soochow University, Suzhou 215011, China
[ 6 ] [Guo, L.]First Affiliated Hospital of Soochow University, Suzhou 215011, China
[ 7 ] [Hu, R.L.]Department of Thoracic Surgery, Hangzhou First People's Hospital, Hangzhou 310006, China
[ 8 ] [Gao, B.]College of Medicine, Soochow University, SIP, Suzhou 215123, China
[ 9 ] [Huang, M.]College of Medicine, Soochow University, SIP, Suzhou 215123, China
[ 10 ] [Cheng, L.F.]College of Medicine, Soochow University, SIP, Suzhou 215123, China
[ 11 ] [Liu, G.H.]Respiration Department, Suzhou Municipal Hospital (East-Section), Suzhou 215001, China
[ 12 ] [Wang, Y.Q.]Key Laboratory of Environmental Materials and Engineering of Jiangsu Province, Yangzhou University, Yangzhou 225002, China

Reprint 's Address：

[Hong, R.Y.]Soochow University, Chemical Engineering Department, No. 199, Ren-Ai St., Suzhou, Jiangsu, 215123, China

Email：

rhong@suda.edu.cn

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Source ：

Applied Surface Science

ISSN： 0169-4332

Year： 2014

Volume： 307

Page： 224-233

2 . 7 1 1

JCR@2014

6 . 3 0 0

JCR@2023

ESI HC Threshold：355

JCR Journal Grade：1

CAS Journal Grade：2

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WoS CC Cited Count：

SCOPUS Cited Count： 107

ESI Highly Cited Papers on the List： 0 Unfold All

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Chinese Cited Count：

30 Days PV： 0

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