Ordered　mesoporous　hydroxyapatite　were　achieved　by　a　areflux　method　in　the　presence　of　non-poisonous　surfactant　(potassiam　polyoxyethylene　laurylether　phosphate,　MAP).　TEM　observations　show　in　the　presence　of　MAP　HAp　crystals　are　oriented　arrangement　with　regular　and　well-defined　channels.　The　size　of　each　channel　are　about　3.5　nm　in　width.　Due　to　the　structure　of　surfactant　and　electrostatic　interaction　between　ionized　surfactant　and　Ca2+　ions,　the　presence　of　MAP　greatly　influence　the　morphology　and　structure　of　the　product.　The　regulating　formation　mechanism　of　hydroxyapatite　nanoclusters　by　MAP　may　extend　the　understanding　of　biomineralization　process　for　the　preparation　of　biomimetic　materials.　©,　2015,　Science　Press.　All　right　reserved.