Monodisperse　iron　oxide　nanocrystals　and　organic　solvents　were　utilized　as　coporogens　in　monolithic　poly(glycidyl　methacrylate-co-ethylene　glycol　dimethacrylate)　capillary　columns　to　afford　stationary　phases　with　enhanced　electrochromatographic　performance　of　small　molecules.　While　the　conventional　monoliths　using　organic　solvents　only　as　a　porogen　exhibited　poor　resolution　(Rs)　＜1.0　and　low　efficiency　of　40000-60000　plates/m,　addition　of　a　small　amount　of　nanocrystals　to　the　polymerization　mixture　provided　increased　resolution　(Rs　＞　3.0)　and　high　efficiency　ranged　from　60000　to　100000　plates/m　at　the　same　linear　velocity　of　0.856　mm/s.　It　was　considered　that　the　mesopores　introduced　by　the　nanocrystals　played　an　important　role　in　the　improvement　of　the　monolith　performance.　This　new　strategy　expanded　the　application　range　of　the　hydrophobic　monoliths　in　the　separation　of　polar　alkaloids　and　narcotics.　The　successful　applications　demonstrated　that　the　glycidyl　methacrylate　based　monoliths　prepared　by　using　nanocrystal　template　are　a　good　alternative　for　enhanced　separation　efficiency　of　small　molecules.　©　2014　WILEY-VCH　Verlag　GmbH　&　Co.　KGaA,　Weinheim.