Marine　organisms　including　bacteria,　fungi,　algae,　sponges,　echinoderms,　mollusks,　and　cephalochordates　produce　a　variety　of　products　with　antifungal　activity　including　bacterial　chitinases,　lipopeptides,　and　lactones;　fungal　(-)-sclerotiorin　and　peptaibols,　purpurides　B　and　C,　berkedrimane　B　and　purpuride;　algal　gambieric　acids　A　and　B,　phlorotannins;　3,5-dibromo-2-(3,5-　dibromo-2-methoxyphenoxy)phenol,　spongistatin　1,　eurysterols　A　and　B,　nortetillapyrone,　bromotyrosine　alkaloids,　bis-indole　alkaloid,　ageloxime　B　and　(-)-ageloxime　D,　haliscosamine,　hamigeran　G,　hippolachnin　A　from　sponges;　echinoderm　triterpene　glycosides　and　alkene　sulfates;　molluscan　kahalalide　F　and　a　1485-Da　peptide　with　a　sequence　SRSELIVHQR;　and　cepalochordate　chitotriosidase　and　a　5026.9-Da　antifungal　peptide.　The　antiviral　compounds　from　marine　organisms　include　bacterial　polysaccharide　and　furan-2-yl　acetate;　fungal　macrolide,　purpurester　A,　purpurquinone　B,　isoindolone　derivatives,　alterporriol　Q,　tetrahydroaltersolanol　C　and　asperterrestide　A,　algal　diterpenes,　xylogalactofucan,　alginic　acid,　glycolipid　sulfoquinovosyldiacylglycerol,　sulfated　polysaccharide　p-KG03,　meroditerpenoids,　methyl　ester　derivative　of　vatomaric　acid,　lectins,　polysaccharides,　tannins,　cnidarian　zoanthoxanthin　alkaloids,　norditerpenoid　and　capilloquinol;　crustacean　antilipopolysaccharide　factors,　molluscan　hemocyanin;　echinoderm　triterpenoid　glycosides;　tunicate　didemnin　B,　tamandarins　A　and　B　and;　tilapia　hepcidin　1-5　(TH　1-5),　seabream　SauMx1,　SauMx2,　and　SauMx3,　and　orange-spotted　grouper　β-defensin.　Although　the　mechanisms　of　antifungal　and　antiviral　activities　of　only　some　of　the　aforementioned　compounds　have　been　elucidated,　the　possibility　to　use　those　known　to　have　distinctly　different　mechanisms,　good　bioavailability,　and　minimal　toxicity　in　combination　therapy　remains　to　be　investigated.　It　is　also　worthwhile　to　test　the　marine　antimicrobials　for　possible　synergism　with　existing　drugs.　The　prospects　of　employing　them　in　clinical　practice　are　promising　in　view　of　the　wealth　of　these　compounds　from　marine　organisms.　The　compounds　may　also　be　used　in　agriculture　and　the　food　industry.　©　2014　Springer-Verlag　Berlin　Heidelberg.