Based　on　the　Penzien　model,　a　calculation　model　of　a　structure　in　consideration　of　pile-soil-structure　interaction　(PSSI)　was　established　and　the　vibration　control　equations　of　the　structural　motion　were　derived.　PSSI＇s　effects　on　structural　vibration　control　were　analyzed.　The　effects　of　every　parameter　of　soil　and　structures　on　structural　vibration　control　were　studied.　The　results　showed　that　considering　PSSI,　the　structural　earthquake　response　is　increased,　the　control-effect　is　reduced,　the　control　force　is　increased;　the　equivalent　shear　wave　velocity　of　soil,　the　rotary　inertia　of　pile　and　the　natural　period　of　upper　structure　have　significant　effects　on　structural　vibration　control　to　some　extent.