Preparation of chiral monolithic column with covalently bonded cellulose and their application to rapid enantioseparation - Details

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Abstract：

A　chiral　monolithic　capillary　column　for　rapid　enantioseparation　was　prepared　by　covalently　bonding　of　cellulose　tris(4-methylbenzoate)　(CTMB)　on　N-acryloxysuccinimide-based　monolith.　The　preparation　and　derivatization　conditions　of　the　monolithic　column　were　optimized.　The　successful　grafting　of　CTMB　was　confirmed　on　the　characterizations　of　the　infrared　spectrum　and　the　cathodic　electroosmotic　flow　(EOF).　The　effects　of　acetic　acid　concentration　and　methanol　content　on　the　enantioseparation　were　studied.　The　solvent　resistance,　reproducibility　and　stability　of　the　monolithic　column　have　also　been　investigated.　The　rapid　enantioseparation　of　the　five　solutes　(phenylalanine,　tyrosine,　tryptophan,　propranolol　and　phenylethanol)　with　resolution　(Rs)　values　up　to　1.31　was　achieved　within　1.2　min　on　the　prepared　chiral　capillary　monolithic　column　by　capillary　electrochromatography.

Keyword：

Capillary electrochromatography (CEC); Cellulose tris(4-methylbenzoate); Chiral monolithic capillary column; Covalent bonding; Rapid enantioseparation

Community：

[ 1 ] [Wang, J.]Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou 350002, China
[ 2 ] [Wang, X.]Institute of Food Safety and Environmental Monitoring, Fuzhou University, Fuzhou 350108, China
[ 3 ] [Li, J.]Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou 350002, China
[ 4 ] [Lü, H.]College of Materials Science and Engineering, Fuzhou University, Fuzhou 350108, China
[ 5 ] [Lin, X.]Institute of Food Safety and Environmental Monitoring, Fuzhou University, Fuzhou 350108, China
[ 6 ] [Xie, Z.]Institute of Food Safety and Environmental Monitoring, Fuzhou University, Fuzhou 350108, China
[ 7 ] [Zhang, Q.]Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou 350002, China

Reprint 's Address：

[Zhang, Q.]Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou 350002, China

Email：

zhangqiq@126.com

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Source ：

Chinese Journal of Chromatography (Se Pu)

ISSN： 1000-8713

Year： 2011

Issue： 12

Volume： 29

Page： 1222-1229

1 . 2 0 0

JCR@2023

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SCOPUS Cited Count： 3

ESI Highly Cited Papers on the List： 0 Unfold All

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30 Days PV： 0

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