An ultrasensitive colorimeter assay strategy for p53 mutation assisted by nicking endonuclease signal amplification - Details

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Abstract：

A　novel　catalytic　colorimetric　assay　assisted　by　nicking　endonuclease　signal　amplification　(NESA)　was　developed.　With　the　signal　amplification,　the　detection　limit　of　the　p53　target　gene　can　be　as　low　as　1　pM,　which　is　nearly　5　orders　of　magnitude　lower　than　that　of　other　previously　reported　colorimetric　DNA　detection　strategies　based　on　catalytic　DNAzyme.　©　2011　The　Royal　Society　of　Chemistry.

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[ 1 ] [Lin, Z.]Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety, Fuzhou University, Fuzhou, Fujian 350002, China
[ 2 ] [Yang, W.]Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety, Fuzhou University, Fuzhou, Fujian 350002, China
[ 3 ] [Zhang, G.]Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety, Fuzhou University, Fuzhou, Fujian 350002, China
[ 4 ] [Liu, Q.]MOE Key Laboratory for Strength and Vibration, Xi'An Jiaotong University, 710049, China
[ 5 ] [Qiu, B.]Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety, Fuzhou University, Fuzhou, Fujian 350002, China
[ 6 ] [Cai, Z.]Department of Chemistry, Hong Kong Baptist University, Hong Kong, Hong Kong
[ 7 ] [Chen, G.]Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety, Fuzhou University, Fuzhou, Fujian 350002, China

Reprint 's Address：

[Lin, Z.]Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety, Fuzhou University, Fuzhou, Fujian 350002, China

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zylin@fzu.edu.cn

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Chemical Communications

ISSN： 1359-7345

Year： 2011

Issue： 32

Volume： 47

Page： 9069-9071

6 . 1 6 9

JCR@2011

4 . 3 0 0

JCR@2023

JCR Journal Grade：1

CAS Journal Grade：2

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ESI Highly Cited Papers on the List： 0 Unfold All

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30 Days PV： 3

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