Despite　drug　eluting　stents　(DESs)　have　revolutionized　the　interventional　cardiology　over　the　past　decade　since　the　first　DES　became　commercially　available　nearly　a　decade　ago,　burst　release　of　loaded　drugs　and　late　thrombosis　caused　by　polymer　coatings　of　the　stents　are　high　concerned.　In　this　situation,　inorganic　coatings,　such　as　silica-based　hybrid　materials,　have　aroused　researcher＇s　interest.　In　this　study,　aspirin　(ASA)　was　incorporated　into　the　sol-gel　derived　silica　matrix　with　polyethylene　glycol　(PEG)　as　an　organic　modifier　to　improve　the　flexibility　and　extensibility　of　the　inorganic　matrices.　We　also　used　L-3,4-dihydroxyphenylalanine　(L-DOPA)　as　a　bio-adhesive　reagent　to　enhance　interface　adhesion　between　the　coating　materials　and　the　316L　stainless　steel　substrate.　The　results　show　that　the　introduction　of　D-LOPA　can　greatly　improve　the　coating　quality　by　enhancement　of　uniformity　and　adhesion.　The　loading　ASA　was　slowly　released　from　the　coatings　and　burst　release　was　effectively　inhibited　owing　to　the　encapsulation　of　ASA　molecules　in　the　silica-PEG　matrices.　©　(2011)　Trans　Tech　Publications.