Login | Cas Login
English| 简体中文| 繁体中文

  • Complex
  • Title
  • Keyword
  • Abstract
  • Scholars
  • Journal
  • ISSN
  • Conference
成果搜索

Advanced Search

author：

Yang, F. (Yang, F..) [1] | Xia, S. (Xia, S..) [2] | Liu, Z. (Liu, Z..) [3] | Chen, J. (Chen, J..) [4] | Lin, Y. (Lin, Y..) [5] | Qiu, B. (Qiu, B..) [6] | Chen, G. (Chen, G..) [7]

Indexed by：

Scopus

Abstract：

A　method　for　the　determination　of　methylene　blue　(MB)　and　its　metabolites　(azure　A,　azure　B　and　azure　C)　in　rat　blood　by　CE-electrospray　ionization　mass　spectrometry　(CE-ESI-MS)　was　developed　in　this　paper.　Different　analytical　parameters　were　investigated　in　detail　such　as　pH　and　concentration　of　separation　buffer,　and　ESI-MS　instrumental　parameters.　Under　the　optimum　conditions,　MB　and　its　metabolites　were　separated　and　detected　in　27.3min.　LODs　(defined　as　S/N=3)　of　this　method　were　0.22,　0.25,　0.10　and　0.30μg/mL　for　MB,　azure　A,　azure　B　and　azure　C,　respectively.　To　get　a　satisfactory　extraction　efficiency　of　MB　and　its　metabolites　in　rat　blood,　different　extraction　solutions　were　studied.　By　using　this　method,　MB　and　its　metabolites　(azure　A,　azure　B　and　azure　C)　were　successfully　analyzed　in　rat　blood　samples.　©　2011　WILEY-VCH　Verlag　GmbH　&　Co.　KGaA,　Weinheim.

Keyword：

CE-ESI-MS; Metabolites; Methylene blue; Rat blood

Community：

  • [ 1 ] [Yang, F.]Ministry of Education Key Laboratory of Analysis and Detection Technology for Food Safety, Department of Chemistry, Fuzhou University, Fuzhou, Fujian, China
  • [ 2 ] [Yang, F.]Fujian Entry-exit Inspection and Quarantine Bureau, Fuzhou, Fujian, China
  • [ 3 ] [Xia, S.]Ministry of Education Key Laboratory of Analysis and Detection Technology for Food Safety, Department of Chemistry, Fuzhou University, Fuzhou, Fujian, China
  • [ 4 ] [Liu, Z.]Fujian Entry-exit Inspection and Quarantine Bureau, Fuzhou, Fujian, China
  • [ 5 ] [Chen, J.]Fujian Entry-exit Inspection and Quarantine Bureau, Fuzhou, Fujian, China
  • [ 6 ] [Lin, Y.]Fujian Entry-exit Inspection and Quarantine Bureau, Fuzhou, Fujian, China
  • [ 7 ] [Qiu, B.]Ministry of Education Key Laboratory of Analysis and Detection Technology for Food Safety, Department of Chemistry, Fuzhou University, Fuzhou, Fujian, China
  • [ 8 ] [Chen, G.]Ministry of Education Key Laboratory of Analysis and Detection Technology for Food Safety, Department of Chemistry, Fuzhou University, Fuzhou, Fujian, China

Reprint 's Address：

  • [Chen, G.]Department of Chemistry, Fuzhou University, Fuzhou, Fujian 350002, China

Email：


gnchen@fzu.edu.cn
Show more details

Related Keywords：

Related Article：

Source ：

Electrophoresis

ISSN： 0173-0835

Year： 2011

Issue： 6-7

Volume： 32

Page： 659-664

3 . 3 0 3

JCR@2011

3 . 0 0 0

JCR@2023

JCR Journal Grade：1

CAS Journal Grade：2

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count： 7

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 1

Affiliated Colleges：

Get Fulltext

DOI Library Discovery Baidu Scholar Search SCOPUS
Online/Total：200/10000526
Address：FZU Library(No.2 Xuyuan Road, Fuzhou, Fujian, PRC Post Code：350116) Contact Us：0591-22865326
Copyright：FZU Library Technical Support：Beijing Aegean Software Co., Ltd. 闽ICP备05005463号-1