A　novel　drug　agent　named　norfloxacin　biomonomer　was　developed　in　order　to　solve　the　problem　of　low　drug　content,　uneven　drug　distribution,　low　molecular　weight,　and　wide　molecular　weight　distribution　of　polymer　drug,　based　on　polyurethane,　which　was　used　as　an　antibacterial　agent　to　control　the　bacterial　infection　associated　with　biofilm　formation　on　polymeric　materials　used　in　biologic　environments.　In　this　research,　norfloxacin　biomonomer　was　synthesized　by　esterifying　the　compound　of　norfloxacin.　High-performance　liquid　chromatography　system　was　used　to　analyze　the　purity　of　the　final　product　and　intermediate　products,　and　Fourier　transform　infrared　spectrometer　and　mass　spectrum　were　used　to　verify　the　final　product　and　intermediate　products.　The　results　showed　that　the　objective　product　was　developed　successfully.　The　final　product　of　norfloxacin　biomonomer　could　be　incorporated　into　the　polyurethane　as　chain　extender.　©　Higher　Education　Press　and　Springer-Verlag　Berlin　Heidelberg　2010.