Although　the　fibroblast　growth　factor　(FGF)　signaling　axis　plays　important　roles　in　cell　survival,　proliferation,　and　differentiation,　the　molecular　mechanism　underlying　how　the　FGF　elicits　these　diverse　regulatory　signals　is　not　well　understood.　By　using　the　Frs2α　null　mouse　em-bryonic　fibroblast　(MEF)　in　conjunction　with　inhibitors　to　multiple　signaling　pathways,　here　we　report　that　the　FGF　signaling　axis　activates　mTOR　via　the　FGF　receptor　substrate　2α　(FRSα)-mediated　PI3K/Akt　pathway,　and　suppresses　autophagy　activity　in　MEFs.　In　addition,　the　PI3K/Akt　pathway　regulated　mTOR　is　crucial　for　the　FGF　signaling　axis　to　suppress　au-tophagy　in　MEFs.　Since　autophagy　has　been　proposed　to　play　important　roles　in　cell　survival,　proliferation,　and　differentiation,　the　findings　suggest　a　novel　mechanism　for　the　FGF　signaling　axis　to　transmit　regulatory　signals　to　downstream　effectors.　©　Ivyspring　International　Publisher.